Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2)

Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2) Publisher Pubmed

Ghaffari R¹ ; Mortazavi M¹ ; Anvari P¹ ; Salamat Rad A¹ ; Alipour F¹ ; Hafezi F^{2, 3, 4, 5} ; Asgari S⁶ ; Hashemi H⁶

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1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Laboratory for Ocular Cell Biology Laboratory, University of Geneva, Geneva, Switzerland
3. Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland
4. Department of Ophthalmology, University of Southern California, Los Angeles, CA, United States
5. ELZA Institute, Dietikon, Switzerland
6. Noor Ophthalmology Research Center, Noor Eye Hospital, No. 96 Esfandiar Boulevard, Vali'asr Avenue, Tehran, Iran

Source: Eye (Basingstoke) Published:2018

Abstract

PurposeTo investigate intraoperative anterior segment optical coherence tomography (AS-OCT) to compare pachymetry changes between two methods (group 1: speculum-on, group 2: speculum-off during riboflavin instillation stage) during corneal cross-linking /CXL) (9 mW/cm 2 for 10 min) in keratoconic patients.MethodsIn this interventional case series, 11 eyes (11 patients) in group 1 and 14 eyes (14 patients) in group 2 were enrolled. Pachymetry measurements by spectral domain OCT was performed at baseline, after epithelial removal, after 30 min of imbibition with riboflavin, and after UV irradiation. Repeated measures analysis of variance was used to compare the trend of changes in different stages of the procedure within and between two groups.ResultsThe corneal thinnest pachymerty (CTP) at baseline, after epithelial removal, 30 min of riboflavin instillation, and irradiation was 469.8±26.5, 438.0±27.1, 354.3±28.4, 367.1±31.8 microns in group 1 and 463.2±25.1, 438.0±27.1, 421.6±54.0, 386.9±34.0 microns in group 2, respectively. Group 1 showed a significantly greater decrease in the corneal pachymetry (P<0.001) during riboflavin instillation, while in group 2 a greater decrease in CTP was observed during the UV irradiation phase (P=0.002).ConclusionsUsing the intraoperative OCT, the speculum-off group had a more stable corneal pachymetry during riboflavin instillation time. Despite this, the effect was not lasting throughout the procedure; significant changes were noted in the corneal pachymetry at the end of operation in both groups; further highlighting the limitations imposed by corneal stromal shrinkage using isotonic dextran containing riboflavin solution for CXL. © The Author(s) 2018.

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Style	Citing Format
MLA	Ghaffari R, et al.. "Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2)." Eye (Basingstoke), vol. 32, no. 3, 2018, pp. 579-585.
APA	Ghaffari R, Mortazavi M, Anvari P, Salamat Rad A, Alipour F, Hafezi F, Asgari S, Hashemi H (2018). Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2). Eye (Basingstoke), 32(3), 579-585.
Chicago	Ghaffari R, Mortazavi M, Anvari P, Salamat Rad A, Alipour F, Hafezi F, Asgari S, Hashemi H. "Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2)." Eye (Basingstoke) 32, no. 3 (2018): 579-585.
Harvard	Ghaffari R et al. (2018) 'Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2)', Eye (Basingstoke), 32(3), pp. 579-585.
Vancouver	Ghaffari R, Mortazavi M, Anvari P, Salamat Rad A, Alipour F, Hafezi F, et al.. Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2). Eye (Basingstoke). 2018;32(3):579-585.
BibTex	@article{ author = {Ghaffari R and Mortazavi M and Anvari P and Salamat Rad A and Alipour F and Hafezi F and Asgari S and Hashemi H}, title = {Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2)}, journal = {Eye (Basingstoke)}, volume = {32}, number = {3}, pages = {579-585}, year = {2018} }
RIS	TY - JOUR AU - Ghaffari R AU - Mortazavi M AU - Anvari P AU - Salamat Rad A AU - Alipour F AU - Hafezi F AU - Asgari S AU - Hashemi H TI - Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2) JO - Eye (Basingstoke) VL - 32 IS - 3 SP - 579 EP - 585 PY - 2018 ER -

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