Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Clinical Results With Two Different Pharmaceutical Preparations of Riboflavin in Corneal Cross-Linking: An 18-Month Follow Up Publisher Pubmed



Hashemi H1 ; Seyedian MA1 ; Miraftab M1 ; Bahrmandy H1 ; Sabzevari A1 ; Asgari S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Noor Ophthalmology Research Center, Noor Eye Hospital, No. 96 Esfandiar Blvd., Vali'asr Ave, Tehran, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, International Campus (TUMS-IC), Tehran, Iran

Source: DARU# Journal of Pharmaceutical Sciences Published:2015


Abstract

Background: Comparison of long-term clinical results of two different pharmaceutical formulations used in corneal cross-linking (CXL) in keratoconus patients. Methods: Sixty eyes of 60 keratoconus patients underwent CXL in two groups. We used riboflavin preparations from Sina Darou, Iran in group A, and Streuli Pharma, Switzerland in group B. Here we made inter-group comparison of changes in vision, refraction, Pentacam indices, corneal biomechanical indices, and endothelial cell count (ECC) 18 months after CXL. Results: Since four patients were lost to follow-up, 56 eyes (28 eyes in each group) were compared. Mean improvement in uncorrected visual acuity (UCVA) was 0.31 ± 0.65 LogMAR (P = 0.014) in group A and 0.24 ± 0.62 Log MAR (P = 0.082) in group B. Best corrected visual acuity (BCVA) remained quite unchanged in both groups (P = 0.774). Mean spherical refractive error reduced by 0.45 ± 1.15 diopter (D) (P = 0.041) in group A and 0.27 ± 1.73 D (P = 0.458) in group B (P = 0.655). Cylinder error and spherical equivalent had a similar trend without any change. Max-K (P = 0.006) and mean-K (P = 0.044) decreased significantly more in group A compared to group B. The reduction in CCT was significantly more in group A than group B (P = 0.004). Q-value was quite unchanged in both groups (P = 0.704). The inter-group difference in CH reduction was borderline significant statistically (P = 0.057). Changes in corneal resistance factor and endothelial cell count were not significantly different between two groups (P = 0.117 and P = 0.229). Conclusion: Clinical results of CXL with the domestic preparation of riboflavin are similar to that achieved with the Swiss made product in some aspects, and it is the preferred brand in some other aspects. This study will continue to report longer follow-up results. © 2015 Hashemi et al.
Related Docs
View other Related Docs
1. Short-Term Comparison of Accelerated and Standard Methods of Corneal Collagen Crosslinking, Journal of Cataract and Refractive Surgery (2015)
2. Matched Comparison Study of Total and Partial Epithelium Removal in Corneal Cross-Linking, Journal of Refractive Surgery (2015)
3. Long-Term Results of an Accelerated Corneal Cross-Linking Protocol (18 Mw/Cm2) for the Treatment of Progressive Keratoconus, American Journal of Ophthalmology (2015)
4. Updates on Corneal Collagen Cross-Linking: Indications, Techniques and Clinical Outcomes, Journal of Current Ophthalmology (2017)
5. Corneal Curvature Changes and Uncorrected Distance Visual Acuity After Corneal Collagen Cross-Linking for Progressive Keratoconus: A One Year Follow-Up Survey, Biomedical and Pharmacology Journal (2015)
6. The Efficacy of Standard Versus Accelerated Epi-Off Corneal Cross-Linking Protocols: A Systematic Review and Sub-Group Analysis, International Ophthalmology (2019)
7. Effect of Corneal Cone Location on Corneal Curvature Changes and Uncorrected Distance Visual Acuity After Corneal Collagen Cross-Linking for Progressive Keratoconus: A One-Year Survey, Biosciences Biotechnology Research Asia (2015)
8. Corneal Biomechanical Outcome of Collagen Cross-Linking in Keratoconic Patients Evaluated by Corvis St, European Journal of Ophthalmology (2021)
Experts (# of related papers)
View all Related Experts
Akbar Fotouhi (5)
Mehrdad Mohammadpour (2)
Other Related Docs
9. Intraoperative Optical Coherence Tomography to Evaluate the Effect of the Eyelid Speculum on Corneal Pachymetry During Accelerated Corneal Cross-Linking (9 Mw/Cm2), Eye (Basingstoke) (2018)
10. Mesopic Visual Quality After Accelerated Corneal Cross Linking: A 12-Month Follow-Up Study, Journal of Current Ophthalmology (2017)
11. Mesopic Quality of Vision After Accelerated 18 Mw/Cm2 Corneal Cross-Linking: Mid-Term Results, Middle East African Journal of Ophthalmology (2017)
12. Photopic, Mesopic, and Scotopic Visual Acuity After 18 Mw/Cm2 Accelerated Corneal Cross-Linking, Eye and Contact Lens (2018)
13. Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus, Journal of Current Ophthalmology (2018)
14. Corneal Cross-Linking Treatment of Keratoconus, Oman Journal of Ophthalmology (2015)
15. Opd Scan Iii Accuracy: Topographic and Aberrometric Indices After Accelerated Corneal Cross-Linking, Journal of Current Ophthalmology (2018)
16. Higher-Order Aberration 4 Years After Corneal Collagen Cross-Linking, Indian Journal of Ophthalmology (2017)
17. Corneal Collagen Cross-Linking in Keratoconus: Primum Non Nocere, Eye (Basingstoke) (2018)
18. Corneal Collagen Cross-Linking in the Treatment of Progressive Keratoconus: A Randomized Controlled Contralateral Eye Study, Middle East African Journal of Ophthalmology (2015)
19. Accelerated Corneal Collagen Cross-Linking in Pediatric Keratoconus, Journal of Current Ophthalmology (2021)
20. Subclinical Inflammatory Response: Accelerated Versus Standard Corneal Cross-Linking, Ocular Immunology and Inflammation (2019)
21. Lens Densitometry After Corneal Cross-Linking in Patients With Keratoconus Using a Scheimpflug Camera, Journal of Ophthalmic and Vision Research (2015)
22. Updates on Managements for Keratoconus, Journal of Current Ophthalmology (2018)
23. Multi Modal Imaging in Corneal Edema After Corneal Collagen Cross-Linking (Cxl); a Case-Based Literature Review, BMC Ophthalmology (2021)
24. Mid-Term Results of a Single Intrastromal Corneal Ring Segment for Mild to Moderate Progressive Keratoconus, Cornea (2017)
25. Standard and Accelerated Corneal Cross-Linking Long-Term Results: A Randomized Clinical Trial, European Journal of Ophthalmology (2020)
26. One-Year Non-Comparative Observational Study to Evaluate Corneal Tomographic, Densitometric, and Aberrometric Features Following Accelerated Corneal Cross-Linking in Progressive Keratoconus, International Ophthalmology (2023)
27. Corneal Biomechanics After Accelerated Cross-Linking: Comparison Between 18 and 9 Mw/Cm2 Protocols, Journal of Refractive Surgery (2017)