Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus

Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus Publisher

Asgari S¹ ; Hashemi H² ; Hajizadeh F² ; Miraftab M³ ; Seyedian MA² ; Amanzadeh K² ; Mehravaran S⁴ ; Fotouhi A¹

Show Affiliations

1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
3. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
4. Stein Eye Institute, University of California, Los Angeles, CA, United States

Source: Journal of Current Ophthalmology Published:2018

Abstract

Purpose: To determine the changes in the depth of the demarcation line in the central to peripheral cornea following accelerated compared to standard corneal cross-linking (CXL). Methods: In this prospective, non-randomized study, 60 eyes with progressive keratoconus underwent accelerated or standard CXL (30 in each group). Anterior segment optical coherence tomography (AS-OCT) was done one month later by two independent masked examiners to measure the depth of the demarcation line in the central cornea and on peripheral rings. Results: The inter-examiner agreement (intra-class correlation coefficient) was >0.75 for all measured points, and average measurements were used in the analysis. The depth of the visualized demarcation line in the center was 223.4 ± 67.4 μm and 354.9 ± 79.0 μm in the accelerated and standard groups, respectively (P < 0.001). The depth significantly decreased from the center to the 7 mm ring in both groups (all P < 0.05). This change was 7.7–26.1% and 2.2%–11.1% in the accelerated and standard groups, respectively. In the accelerated group, the demarcation line was deeper in the central cone sub-group compared to the inferior cone sub-group, but in the standard group, the demarcation line was deeper in the inferior cone sub-group (all P < 0.05). Cases with an inferior cone showed greater inter-group differences in all studied points. Conclusions: The depth of the demarcation line with accelerated CXL is less than the standard protocol and decreases from the center towards the periphery. Demarcation lines are more homogenized with standard CXL. In cases with an inferior cone, demarcation line depth varies throughout the cornea. © 2017 Iranian Society of Ophthalmology

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Akbar Fotouhi (4)

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Style	Citing Format
MLA	Asgari S, et al.. "Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus." Journal of Current Ophthalmology, vol. 30, no. 3, 2018, pp. 223-227.
APA	Asgari S, Hashemi H, Hajizadeh F, Miraftab M, Seyedian MA, Amanzadeh K, Mehravaran S, Fotouhi A (2018). Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus. Journal of Current Ophthalmology, 30(3), 223-227.
Chicago	Asgari S, Hashemi H, Hajizadeh F, Miraftab M, Seyedian MA, Amanzadeh K, Mehravaran S, Fotouhi A. "Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus." Journal of Current Ophthalmology 30, no. 3 (2018): 223-227.
Harvard	Asgari S et al. (2018) 'Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus', Journal of Current Ophthalmology, 30(3), pp. 223-227.
Vancouver	Asgari S, Hashemi H, Hajizadeh F, Miraftab M, Seyedian MA, Amanzadeh K, et al.. Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus. Journal of Current Ophthalmology. 2018;30(3):223-227.
BibTex	@article{ author = {Asgari S and Hashemi H and Hajizadeh F and Miraftab M and Seyedian MA and Amanzadeh K and Mehravaran S and Fotouhi A}, title = {Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus}, journal = {Journal of Current Ophthalmology}, volume = {30}, number = {3}, pages = {223-227}, year = {2018} }
RIS	TY - JOUR AU - Asgari S AU - Hashemi H AU - Hajizadeh F AU - Miraftab M AU - Seyedian MA AU - Amanzadeh K AU - Mehravaran S AU - Fotouhi A TI - Multipoint Assessment of Demarcation Line Depth After Standard and Accelerated Cross-Linking in Central and Inferior Keratoconus JO - Journal of Current Ophthalmology VL - 30 IS - 3 SP - 223 EP - 227 PY - 2018 ER -

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