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Association Between Metabolic Syndrome and Risk of Endometrial Cancer; a Systematic Review and Meta-Analysis Publisher



Abbasi S1 ; Rezaei J2 ; Bazi F3 ; Mousavi MA4 ; Rassouli S5 ; Zamanpour Z6 ; Hosseini E7 ; Noori M8 ; Madani ZH9
Authors
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Authors Affiliations
  1. 1. Department of Gynecology and Obstetrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Critical Care Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Reproductive Health and Midwifery, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Gynecology and Obstetrics, Imam Hossein Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gynecology and Obstetrics, Imam Khomeini Hospital, School of Medicine, Sari University of Medical Sciences, Sari, Iran
  6. 6. Department of Gynecology and Obstetrics, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Department of Gynecology and Obstetrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Department of Gynecology and Obstetrics, Shahid Akbarabadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Reproductive Health Research Center, Department of Gynecology and Obstetrics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Immunopathologia Persa Published:2025


Abstract

Introduction: Endometrial cancer is one of the most prevalent female malignancies, with various factors, including metabolic syndrome, contributing to its incidence. Thus, this study aims to evaluate the association between metabolic syndrome and the risk of endometrial carcinoma. Materials and Methods: In this systematic review and meta-analysis, two independent authors searched electronic databases, including Cochrane, PubMed, ProQuest, Web of Science, and the Google Scholar search engine up to May 16, 2024. Data analysis was conducted using STATA 14 software with a significance level of P < 0.05 for all tests. Results: A pooled analysis of 12 observational studies found that metabolic syndrome elevated the risk of endometrial carcinoma by 37% overall (OR: 1.37, 95% CI: 1.33, 1.42), 35% in cohort studies (OR: 1.35, 95% CI: 1.29, 1.42), and 40% in case-control studies (OR: 1.40, 95% CI: 1.33, 1.48). However, hypertension increased the risk of endometrial carcinoma by 25% (OR: 1.25, 95% CI: 1.18, 1.33), fasting hyperglycemia by 25% (OR: 1.25, 95% CI: 1.15, 1.37), hypertriglyceridemia by 17% (OR: 1.17, 95% CI: 1.13, 1.21), low high density lipoprotein (HDL) by 20% (OR:1.20, 95% CI: 1.12, 1.28), increased waist circumference by 59% (OR:1.59, 95% CI: 1.43, 1.77), pre-menopausal period by 67% (OR:1.67, 95% CI: 1.38, 2.02), and post-menopausal period by 61% (OR: 1.61, 95% CI: 1.17, 2.21). Likewise, obesity almost doubled the risk of endometrial carcinoma (OR: 2.13, 95% CI: 1.65, 2.75). Conclusion: Metabolic syndrome increases the risk of endometrial carcinoma, with obesity being the most dangerous risk factor for endometrial cancer. Thus, managing metabolic disorders in women can be an important step toward reducing the incidence of endometrial cancer. © 2025 The Author(s)
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