The Value of Epidermal Growth Factor Receptor Expression in Predicting Aggressive Behaviors of Bladder Neoplasms Publisher



Yazdi SAM¹ ; Asghari F¹ ; Tabriz HM¹ ; Vesali B¹ ; Nazar E¹ Show Affiliations
Source: Nephro-Urology Monthly Published:2023

Abstract

Background: It has been shown that some cancers express the epidermal growth factor receptor (EGFR). Several variables influence bladder cancer prognosis, including stage, grade, and gene expression. Objectives: We used immunohistochemistry to measure the prevalence and prognostic significance of EGFR expression in bladder tumors in our population. Methods: Thirty bladder tumors were the subjects of this cross-sectional study. To evaluate the biological behavior of the tumors, histopathological analysis was performed. We carried out EGFR immunohistochemical staining to evaluate gene expression. Results: EGFR was expressed in 25 (83.3%) patients. Expression of this biomarker was independent of tumor characteristics such as lymphatic invasion, muscle invasion, and tumor grade and stage (P value > 0.05). Conclusions: Remembering each patient’s tumor characteristics determine that prognosis is crucial. The prognostic value of EGFR expression in predicting aggressive behavior in bladder tumors is marginal, but it is necessary to evaluate therapeutic response. © 2023, Author(s).