Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open

Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma Publisher Pubmed

Fard MA¹ ; Afzali M¹ ; Abdi P¹ ; Yasseri M² ; Ebrahimi KB³ ; Moghimi S¹

Show Affiliations

1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran
3. Mason Eye Institute, Columbia, MO, United States

Source: Investigative Ophthalmology and Visual Science Published:2016

Abstract

PURPOSE. To compare the pattern of macular ganglion cell plus inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thickness changes in moderate to severe primary open–angle glaucoma (POAG) with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography (OCT) auto-segmentation. METHODS. A total of 138 eyes (42 eyes with chronic unilateral NAION and their 42 unaffected fellow eyes, 32 eyes of 32 moderate to severe glaucoma patients, and 22 eyes of 22 healthy normal subjects) underwent neuro-ophthalmologic examinations and spectral-domain OCT in a cross-sectional study at a single academic institution. GCIPL and total retinal thicknesses were obtained from 20° by 20° cube scans of the macula centered around the fovea. The scanned region was divided into two concentric regions (inner and outer, with diameters of 3 and 6 mm, respectively) and eight sectors (four sectors in each of the inner and outer regions). Peripapillary RNFL thickness was also measured. RESULTS. Peripapillary RNFL, total macula, and GCIPL were significantly thinner in NAION and POAG eyes compared to unaffected fellow eyes of NAION and to age-matched healthy control eyes in all eight sectors (P < 0.001). There was no significant difference in peripapillary RNFL, total macula, and outer region GCIPL thicknesses between the affected eyes of the patients with NAION and glaucoma patients. However, the inner region GCIPL was significantly thinner in NAION eyes compared to POAG eyes after adjusting for age, sex, and mean deviation of the visual field (P = 0.001). Also, the GCIPL sector thicknesses were more strongly correlated with visual acuity than were the macular sectors in all patients (most sectors P ≤ 0.001). CONCLUSIONS. Patients with NAION show differences in the tissue damage with greater loss of parafoveal GCIPL tissue thickness compared to patients with POAG. © 2016, Association for Research in Vision and Ophthalmology Inc. All rights reserved.

Related Docs

View other Related Docs

1. Retinal Ganglion Cell Loss Precedes Retinal Nerve Fiber Thinning in Nonar Teritic Anterior Ischemic Optic Neuropathy, Journal of Neuro-Ophthalmology (2016)

2. Optical Coherence Tomography in Ischemic Optic Neuropathy, Annals of Eye Science (2020)

3. Peripapillary Choroidal Thickness in Nonarteritic Anterior Ischemic Optic Neuropathy, Investigative Ophthalmology and Visual Science (2015)

4. Associations of Refractive Errors and Retinal Changes Measured by Optical Coherence Tomography: A Systematic Review and Meta-Analysis, Survey of Ophthalmology (2022)

5. Choroidal Thickness in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy, Journal of Ophthalmic and Vision Research (2020)

6. Optic Nerve Head Morphology in Nonarteritic Anterior Ischemic Optic Neuropathy Compared to Open-Angle Glaucoma, Investigative Ophthalmology and Visual Science (2016)

7. Optic Nerve Head Cupping in Glaucomatous and Non-Glaucomatous Optic Neuropathy, British Journal of Ophthalmology (2019)

8. Oct and Glaucoma: Interpretation, Diagnostics in Ocular Imaging: Cornea# Retina# Glaucoma and Orbit (2020)

Experts (# of related papers)

View all Related Experts

Masoud Aghsaei Fard (7)

Parisa Abdi (3)

Style	Citing Format
MLA	Fard MA, et al.. "Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma." Investigative Ophthalmology and Visual Science, vol. 57, no. 3, 2016, pp. 1011-1016.
APA	Fard MA, Afzali M, Abdi P, Yasseri M, Ebrahimi KB, Moghimi S (2016). Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma. Investigative Ophthalmology and Visual Science, 57(3), 1011-1016.
Chicago	Fard MA, Afzali M, Abdi P, Yasseri M, Ebrahimi KB, Moghimi S. "Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma." Investigative Ophthalmology and Visual Science 57, no. 3 (2016): 1011-1016.
Harvard	Fard MA et al. (2016) 'Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma', Investigative Ophthalmology and Visual Science, 57(3), pp. 1011-1016.
Vancouver	Fard MA, Afzali M, Abdi P, Yasseri M, Ebrahimi KB, Moghimi S. Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma. Investigative Ophthalmology and Visual Science. 2016;57(3):1011-1016.
BibTex	@article{ author = {Fard MA and Afzali M and Abdi P and Yasseri M and Ebrahimi KB and Moghimi S}, title = {Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma}, journal = {Investigative Ophthalmology and Visual Science}, volume = {57}, number = {3}, pages = {1011-1016}, year = {2016} }
RIS	TY - JOUR AU - Fard MA AU - Afzali M AU - Abdi P AU - Yasseri M AU - Ebrahimi KB AU - Moghimi S TI - Comparison of the Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Between Ischemic Optic Neuropathy and Open–Angle Glaucoma JO - Investigative Ophthalmology and Visual Science VL - 57 IS - 3 SP - 1011 EP - 1016 PY - 2016 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract