A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights

A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights Publisher

Sepehri S^{1, 2} ; Farhadi G³ ; Maghbul M⁴ ; Nasiri F⁴ ; Faramarzi MA⁵ ; Mahnam K⁶ ; Mojtabavi S⁵ ; Mahdavi M⁷ ; Moharrami Oranj Z⁴

Show Affiliations

1. Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
2. Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
3. Students Research Committee, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
4. Department of Applied Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran
5. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Biology, Faculty of Sciences, Shahrekord University, Shahrekord, Iran
7. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Heliyon Published:2024

Abstract

One of the multifactorial worldwide health syndromes is diabetes mellitus which is increasing at a disturbing rate. The inhibition of α-glucosidase, an enzyme that catalyzes starch hydrolysis in the intestine, is one helpful therapeutic approach for controlling hyperglycemia related to type-2 diabetes. To discover α-glucosidase inhibitors, some 2-hydrazolyl-4-thiazolidinone hybrids (3a-e) were synthesized from new one-pot reaction procedures. Next, their chemical structures were confirmed by 1H NMR, 13C NMR, and FT-IR spectra, and elemental analysis technique. Then, the α-glucosidase inhibitory activity of the titled compounds was evaluated. Among them, derivatives 3b and 3c revealed the highest activity against α-glucosidase compared to acarbose as a drug. Enzyme kinetic studies of the most active derivative (3b) indicated a competitive inhibition. Finally, molecular modeling studies were accomplished to describe vital interactions of the most potent compounds (3b and 3c) with the α-glucosidase enzyme. © 2024 The Authors

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Mohammad Ali Faramarzi (12)

Mohammad Mahdavi (8)

Style	Citing Format
MLA	Sepehri S, et al.. "A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights." Heliyon, vol. 10, no. 16, 2024, pp. -.
APA	Sepehri S, Farhadi G, Maghbul M, Nasiri F, Faramarzi MA, Mahnam K, Mojtabavi S, Mahdavi M, Moharrami Oranj Z (2024). A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights. Heliyon, 10(16), -.
Chicago	Sepehri S, Farhadi G, Maghbul M, Nasiri F, Faramarzi MA, Mahnam K, Mojtabavi S, Mahdavi M, Moharrami Oranj Z. "A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights." Heliyon 10, no. 16 (2024): -.
Harvard	Sepehri S et al. (2024) 'A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights', Heliyon, 10(16), pp. -.
Vancouver	Sepehri S, Farhadi G, Maghbul M, Nasiri F, Faramarzi MA, Mahnam K, et al.. A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights. Heliyon. 2024;10(16):-.
BibTex	@article{ author = {Sepehri S and Farhadi G and Maghbul M and Nasiri F and Faramarzi MA and Mahnam K and Mojtabavi S and Mahdavi M and Moharrami Oranj Z}, title = {A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights}, journal = {Heliyon}, volume = {10}, number = {16}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Sepehri S AU - Farhadi G AU - Maghbul M AU - Nasiri F AU - Faramarzi MA AU - Mahnam K AU - Mojtabavi S AU - Mahdavi M AU - Moharrami Oranj Z TI - A New Route to the Synthesis of 2-Hydrazolyl-4-Thiazolidinone Hybrids, Evaluation of Α-Glucosidase Inhibitory Activity and Molecular Modeling Insights JO - Heliyon VL - 10 IS - 16 SP - EP - PY - 2024 ER -

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