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Effects of Resistant Starch on Glycemic Control, Serum Lipoproteins and Systemic Inflammation in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials Publisher Pubmed



Halajzadeh J1 ; Milajerdi A2, 3 ; Reiner Z4 ; Amirani E5 ; Kolahdooz F6 ; Barekat M7 ; Mirzaei H5 ; Mirhashemi SM8 ; Asemi Z5
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maraghe University of Medical Science, Maraghe, Iran
  2. 2. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
  5. 5. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada
  7. 7. Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  8. 8. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran

Source: Critical Reviews in Food Science and Nutrition Published:2020


Abstract

The aim of this systematic review and meta-analysis was to evaluate the effects of resistant starch (RS) on glycemic status, serum lipoproteins and inflammatory markers in patients with metabolic syndrome (MetS) and related disorders. Two independent authors systematically searched online database including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until 30 April 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of included trials. The heterogeneity among the included studies was assessed using Cochrane’s Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Nineteen trials were included in this meta-analysis. Administration of RS resulted in significant reduction in fasting plasma glucose (FPG) (14 studies) (WMD: −4.28; 95% CI: −7.01, −1.55), insulin (12 studies) (WMD: −1.95; 95% CI: −3.22, −0.68), and HbA1C (8 studies) (WMD: −0.60; 95% CI: −0.95, −0.24). When pooling data from 13 studies, a significant reduction in total cholesterol levels (WMD: −8.19; 95% CI: −15.38, −1.00) and LDL-cholesterol (WMD: −8.57; 95% CI: −13.48, −3.66) were found as well. Finally, RS administration was associated with a significant decrease in tumor necrosis factor alpha (TNF-α) (WMD: −2.02; 95% CI: −3.14, −0.90). This meta-analysis showed beneficial effects of RS on improving FPG, insulin, HbA1c, total cholesterol, LDL-cholesterol and TNF-α levels in patients with MetS and related disorders, but it did not affect HOMA-IR, triglycerides, HDL-cholesterol, CRP and IL-6 levels. © 2019 Taylor & Francis Group, LLC.
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