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The Protective Effect of the Gallic Acid Against Tnbs-Induced Ulcerative Colitis in Rats: Role of Inflammatory Parameters



Khodayar B1 ; Farzaei MH2, 3 ; Abdolghaffari AH4, 5, 6 ; Bahramsoltani R7 ; Baeeri M6 ; Ziarani FS8 ; Mohammadi M9 ; Rahimi R7 ; Abdollahi M6, 10
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
  5. 5. Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  6. 6. Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmacy in Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Anatomy, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  9. 9. Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  10. 10. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Iranian Medical Council Published:2018

Abstract

Background: Ulcerative Colitis (UC) is an Inflammatory Bowel Disease (IBD) that causes long-lasting inflammation and ulcers in digestive tract. The current study aimed to evaluate the protective effects of gallic acid on the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced UC in rats. Methods: Forty-two adult Wistar rats were divided into seven groups (n=7) and UC was induced in six groups using TNBS solution. They received different daily doses of gallic acid (25, 50, 75 and 100 mg/kg/ day, p.o). On the 11th day, the colon tissues were removed and examined regarding the macroscopic and histopathology lesions. Also, Disease Activity Index (DAI) and Myeloperoxidase (MPO) activity were measured in the colon homogenate. Results: Pretreatment with this natural agent remarkably reduced the macroscopic scores of colon in rats with UC in comparison with the control group. DAI was also reduced by gallic acid significantly. Histopathological findings confirmed the beneficial effects of gallic acidonthe animal model of UC. Gallic acid induced a significant decrease in the levels of inflammatory mediators like MPO. Conclusion: We may conclude that gallic acid can be used as an effective medicine for treatment of UC in animal model, however it needs to be confirmed by human models. © 2018 Journal of Iranian Medical Council. All rights reserved.
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