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Sars-Cov-2 and Pancreas: A Potential Pathological Interaction? Publisher Pubmed



Geravandi S1 ; Mahmoudiaznaveh A2 ; Azizi Z2 ; Maedler K1 ; Ardestani A1, 2
Authors
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Authors Affiliations
  1. 1. Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany
  2. 2. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Trends in Endocrinology and Metabolism Published:2021


Abstract

The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV-2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19–diabetes fatal bidirectional relationship. © 2021 Elsevier Ltd