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Sars-Cov-2 and Pancreas: A Potential Pathological Interaction? Publisher Pubmed



Geravandi S1 ; Mahmoudiaznaveh A2 ; Azizi Z2 ; Maedler K1 ; Ardestani A1, 2
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Source: Trends in Endocrinology and Metabolism Published:2021


Abstract

The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV-2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19–diabetes fatal bidirectional relationship. © 2021 Elsevier Ltd
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