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Micrornas As Biomarkers for Early Diagnosis, Targeting and Prognosis of Prostate Cancer Publisher Pubmed



Azani A1, 2 ; Omran SP3 ; Ghasrsaz H4 ; Idani A3 ; Eliaderani MK5 ; Peirovi N6 ; Dokhani N7 ; Lotfalizadeh MH8 ; Rezaei MM9 ; Ghahfarokhi MS10 ; Karkonshayan S11 ; Hanjani PN12 ; Kardaan Z13 ; Navashenagh JG14 Show All Authors
Authors
  1. Azani A1, 2
  2. Omran SP3
  3. Ghasrsaz H4
  4. Idani A3
  5. Eliaderani MK5
  6. Peirovi N6
  7. Dokhani N7
  8. Lotfalizadeh MH8
  9. Rezaei MM9
  10. Ghahfarokhi MS10
  11. Karkonshayan S11
  12. Hanjani PN12
  13. Kardaan Z13
  14. Navashenagh JG14
  15. Yousefi M15
  16. Abdolahi M16
  17. Salmaninejad A1, 2, 17
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Medicine, Mazandaran University of Medical Sciences, Mazandaran, Iran
  5. 5. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  8. 8. North Khorasan University of Medical Sciences, Bojnurd, Iran
  9. 9. Department of Urology, Faculty of Medicine, Mashhad University of Medical Sciences, Iran
  10. 10. Student Research Committee, Faculty of Medicine, Shahrood University of Medical Sciences, Shahrood, Iran
  11. 11. Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
  12. 12. Department of Genetics, Faculty of Advanced Technologies in Medicine, Golestan University of Medical Science, Gorgan, Iran
  13. 13. Department of Cellular Molecular Biology, Faculty of Life Science and Biotechnology, Shahid Beheshti University, Tehran, Iran
  14. 14. Noncommunicable Disease Research Center, Bam University of Medical Sciences, Bam, Iran
  15. 15. Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  16. 16. Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  17. 17. Regenerative Medicine, Organ Procurement and Transplantation Multi-Disciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Globally, prostate cancer (PC) is leading cause of cancer-related mortality in men worldwide. Despite significant advances in the treatment and management of this disease, the cure rates for PC remains low, largely due to late detection. PC detection is mostly reliant on prostate-specific antigen (PSA) and digital rectal examination (DRE); however, due to the low positive predictive value of current diagnostics, there is an urgent need to identify new accurate biomarkers. Recent studies support the biological role of microRNAs (miRNAs) in the initiation and progression of PC, as well as their potential as novel biomarkers for patients’ diagnosis, prognosis, and disease relapse. In the advanced stages, cancer-cell-derived small extracellular vesicles (SEVs) may constitute a significant part of circulating vesicles and cause detectable changes in the plasma vesicular miRNA profile. Recent computational model for the identification of miRNA biomarkers discussed. In addition, accumulating evidence indicates that miRNAs can be utilized to target PC cells. In this article, the current understanding of the role of microRNAs and exosomes in the pathogenesis and their significance in PC prognosis, early diagnosis, chemoresistance, and treatment are reviewed. © 2023 Elsevier GmbH
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