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Effect of Delayed Photobiomodulation Therapy on Neurosensory Recovery in Patients With Mandibular Nerve Neurotmesis Following Traumatic Mandibular Fracture: A Randomized Triple-Blinded Clinical Trial Publisher Pubmed



Salari B1, 2 ; Nikparto N3, 4 ; Babaei A5, 6 ; Fekrazad R7, 8
Authors
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Authors Affiliations
  1. 1. Department of Orthodontics, Aja University of Medical Sciences, Tehran, Iran
  2. 2. Department of Orthodontics, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Student Research Committee, Faculty of Dentistry, Aja University of Medical Sciences, Tehran, Iran
  4. 4. Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Radiation Sciences Research Center, Laser Research Center in Medical Sciences, Aja University of Medical Sciences, Tehran, Iran
  8. 8. International Network for Photo Medicine and Photo Dynamic Therapy (INPMPDT), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Journal of Photochemistry and Photobiology B: Biology Published:2022


Abstract

Introduction: There is a possibility of neurotmesis of the inferior alveolar nerve (IAN) in mandibular fractures, which leads to neurosensory impairment. In this study, we aimed to investigate the efficacy of photobiomodulation therapy (PBMT) in patients with neurotmesis following trauma and mandibular fracture. Materials and Methods: This triple-blind randomized trial was carried out on patients who suffered neurotmesis of the IAN following mandibular angle and body fracture at least for 6 months. In the intervention group, laser irradiation was applied with a low-level GaAlAs diode laser (continuous wave of 810 nm wavelength, power of 200 mW, and energy density of 12–14 J/cm2). In the control group, the laser probe was turned off and placed on the affected area. LLLT was done for 12 sessions (2 times/week for 6 weeks). Light touch sensations, two-point discrimination, thermal discrimination (cold and warm stimulus), electric pulp test (EPT), and oral health impact profile (OHIP)-14 questionnaire were performed before the intervention, immediately after each PBMT session, and after 3, 6, 9 and 12 months. Results: In both groups, 3 and 23 patients were female and male, respectively. The results showed significantly improved light (cotton swab), light (wooden cotton swab), and sharp (dental needle) touch sensations, and two-point discrimination test in the PBMT group after the 10th, 11th, 10th, and 10th session, respectively. Two-way repeated measure ANOVA revealed that the trend of light touch sensation with cotton swab and two-point discrimination test was statistically significant (p-value = 0.002 and 0.001, respectively). The results of OHIP-14 test showed a significantly higher mean in the PBMT group 3 months after PBMT. There was no statistically significant difference in EPT and thermal discrimination tests regarding the patients' group. Conclusion: PBMT could be an effective treatment for late post-traumatic nerve neurotmesis following a traumatic mandibular fracture. © 2022 Elsevier B.V.
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