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Association of Mir-149 (Rs2292832) Variant With the Risk of Coronary Artery Disease Publisher



Ghaffarzadeh M1 ; Ghaedi H1 ; Alipoor B2 ; Omrani MD3 ; Kazerouni F1 ; Shanaki M1 ; Labbaf A1 ; Pashaiefar H4 ; Rahimipour A1
Authors
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Authors Affiliations
  1. 1. Department of Medical Lab Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran
  3. 3. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Medical Genetics Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Biochemistry Published:2017


Abstract

Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP rs2292832 and the risk of CAD in an Iranian population. Methods: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls). Results: Our analysis revealed that the TT genotype was more frequent in CAD patients than control subjects (P=0.02) implying that TT genotype should be considered as a risk factor in CAD development (TT vs. TC+CC p=0.02, OR=1.88). Conclusions: The present study suggests that rs2292832-TT in pre-miR-149 is associated with CAD in an Iranian population. © 2017 Maryam Ghaffarzadeh et al.
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