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Mirna-Related Polymorphisms in Mir-423 (Rs6505162) and Pex6 (Rs1129186) and Risk of Esophageal Squamous Cell Carcinoma in an Iranian Cohort Publisher Pubmed



Narimansalehfam Z1 ; Bastami M2 ; Somi MH3 ; Behjati F4 ; Mansoori Y1 ; Daraei A5 ; Saadatian Z6 ; Narimansalehfam L7 ; Mahmoodzadeh H8 ; Makhdoumi Y9 ; Tabrizi FV9 ; Ebrahimisharif B10 ; Hezarian A11 ; Naghashi S3 Show All Authors
Authors
  1. Narimansalehfam Z1
  2. Bastami M2
  3. Somi MH3
  4. Behjati F4
  5. Mansoori Y1
  6. Daraei A5
  7. Saadatian Z6
  8. Narimansalehfam L7
  9. Mahmoodzadeh H8
  10. Makhdoumi Y9
  11. Tabrizi FV9
  12. Ebrahimisharif B10
  13. Hezarian A11
  14. Naghashi S3
  15. Abbaszadegan MR12
  16. Tavakkolybazzaz J1
Show Affiliations
Authors Affiliations
  1. 1. Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  5. 5. Genetics Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  6. 6. Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Reza Radiation Oncology Center, Mashhad, Iran
  10. 10. Department of Genetics and Biotechnology, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
  11. 11. Medical Laboratory, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, 9196773117, Iran

Source: Genetic Testing and Molecular Biomarkers Published:2017


Abstract

Aims: Iran is located in the Asian esophageal cancer belt. It is a high-risk region for esophageal squamous cell carcinoma (ESCC). The extent to which genetic components, especially variants within miRNAs or their binding sites, contribute to risk of ESCC in the region is not yet fully understood. Herein, tests were done on an Iranian cohort to evaluate the association of miRNA-related polymorphisms in miR-423 (rs6505162) and peroxisomal biogenesis factor 6 (PEX6) (rs1129186 within a miR-149-5p-binding site) with the risk of ESCC risk. Methods: This study recruited 200 ESCC patients and 300 healthy individuals. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Target genes and biological processes that are regulated by miR-423 and may be affected by a change in miR-423 expression were identified by in silico analysis. Results: Logistic regression analyses revealed an association between rs6505162 and ESCC, assuming codominant (AA vs. CC, odds ratios, OR [95% confidence interval, CI]: 0.32 [0.15-0.69], p-value: 0.0076), recessive (AA vs. CC+CA, OR [95% CI]: 0.35 [0.16-0.73], p-value: 0.0027), and log-additive models (OR [95% CI]: 0.69 [0.52-0.91], p-value: 0.0084). No significant association was observed for PEX6 rs1129186. In silico analyses revealed several genes and biological processes that are regulated by miR-423 in ESCC. Conclusion: This study identified the first evidence of an association of a miRNA-related variant with risk of ESCC in an Iranian cohort. PEX6 rs1129186 may not modulate the risk of ESCC in the cohort. © Copyright 2017, Mary Ann Liebert, Inc. 2017.
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