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In Silico Dissection of Mirna Targetome Polymorphisms and Their Role in Regulating Mirna-Mediated Gene Expression in Esophageal Cancer Publisher Pubmed



Narimansalehfam Z1 ; Bastami M2 ; Somi MH3 ; Samadi N4, 5 ; Abbaszadegan MR6 ; Behjati F7 ; Ghaedi H8 ; Tavakkolybazzaz J1 ; Masotti A9
Authors
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Authors Affiliations
  1. 1. Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Faculty of Advanced Biomedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Biochemistry and Medical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, 9196773117, Iran
  7. 7. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  8. 8. Medical Genetics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Bambino Gesu Children’s Hospital-IRCCS, Gene Expression - Microarrays Laboratory, Viale di San Paolo 15, Rome, 00146, Italy

Source: Cell Biochemistry and Biophysics Published:2016


Abstract

Esophageal cancer is the eighth most common cancer worldwide. Also middle-aged obese adults with higher body mass index during childhood have a greater risk to develop esophageal cancer. The contribution of microRNAs to esophageal cancer has been extensively studied and it became clear that these noncoding RNAs may play crucial roles in pathogenesis, diagnosis and prognosis of the disease. Increasing evidences have suggested that polymorphisms perturbing microRNA targetome (i.e., the compendium of all microRNA target sites) are associated with cancers including esophageal cancer. However, the extent to which such variants contribute to esophageal cancer is still unclear. In this study, we applied an in silico approach to systematically identify polymorphisms perturbing microRNA targetome in esophageal cancer and performed various analyses to predict the functional consequences of the occurrence of these variants. The computational results were integrated to provide a prioritized list of the most potentially disrupting esophageal cancer-implicated microRNA targetome polymorphisms along with the in silico insight into the mechanisms with which such variations may modulate microRNA-mediated regulation. The results of this study will be valuable for future functional experiments aimed at dissecting the roles of microRNA targetome polymorphisms in the onset and progression of esophageal cancer. © 2016, Springer Science+Business Media New York.
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