Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Revisiting Structure-Property Relationship of Ph-Responsive Polymers for Drug Delivery Applications Publisher Pubmed



Bazbanshotorbani S1 ; Hasanisadrabadi MM2, 3 ; Karkhaneh A1 ; Serpooshan V4 ; Jacob KI3, 5 ; Moshaverinia A2 ; Mahmoudi M6, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 15875-4413, Iran
  2. 2. Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, 90095, CA, United States
  3. 3. Parker H. Petit Institute for Bioengineering and Bioscience, G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, 30332, GA, United States
  4. 4. Cardiovascular Institute, Stanford University, 300 Pasteur Dr., Stanford, 94305, CA, United States
  5. 5. School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, 30332, GA, United States
  6. 6. Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
  7. 7. Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States

Source: Journal of Controlled Release Published:2017


Abstract

pH-responsive polymers contain ionic functional groups as pendants in their structure. The total number of charged groups on polymer chains determines the overall response of the system to changes in the external pH. This article reviews various pH-responsive polymers classified as polyacids (e.g., carboxylic acid based polymers, sulfonamides, anionic polysaccharides, and anionic polypeptides) and polybases (e.g., polyamines, pyridine and imidazole containing polymers, cationic polysaccharides, and cationic polypeptides). We correlate the pH variations in the body at the organ level (e.g., gastrointestinal tract and vaginal environment), tissue level (e.g., cancerous and inflamed tissues), and cellular level (e.g., sub-cellular organelles), with the intrinsic properties of pH-responsive polymers. This knowledge could help to select more effective (‘smart’) polymeric systems based on the biological target. Considering the pH differences in the body, various drug delivery systems can be designed by utilizing smart biopolymeric compounds with the required pH-sensitivity. We also review the pharmaceutical application of pH-responsive polymeric carriers including hydrogels, polymer-drug conjugates, micelles, dendrimers, and polymersomes. © 2017 Elsevier B.V.
Related Docs
View other Related Docs
1. Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart internal stimulus-responsive nanocarriers for drug and gene delivery (2015)
2. Ph-Sensitive Stimulus-Responsive Nanocarriers for Targeted Delivery of Therapeutic Agents, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2016)
3. Classification of Stimuli-Responsive Polymers As Anticancer Drug Delivery Systems, Drug Delivery (2015)
4. Controlled Anti-Cancer Drug Release Through Advanced Nano-Drug Delivery Systems: Static and Dynamic Targeting Strategies, Journal of Controlled Release (2020)
5. Could Artificial Intelligence Revolutionize the Development of Nanovectors for Gene Therapy and Mrna Vaccines?, Nano Today (2022)
6. In Situ Bone Tissue Engineering Using Gene Delivery Nanocomplexes, Acta Biomaterialia (2020)
7. Pressure Responsive Nanogel Base on Alginate-Cyclodextrin With Enhanced Apoptosis Mechanism for Colon Cancer Delivery, Journal of Biomedical Materials Research - Part A (2018)
8. Temperature-Responsive Smart Nanocarriers for Delivery of Therapeutic Agents: Applications and Recent Advances, ACS Applied Materials and Interfaces (2016)
Experts (# of related papers)
View all Related Experts
Mehdi Shafee Ardestani (6)
Rassoul Dinarvand (5)
Other Related Docs
9. Microfluidic Fabrication of Alendronate-Loaded Chitosan Nanoparticles for Enhanced Osteogenic Differentiation of Stem Cells, Life Sciences (2020)
10. Biomedical Applications of Intelligent Nanomaterials, Intelligent Nanomaterials: Second Edition (2016)
11. Injectable Hydrogel-Based Drug Delivery Systems for Local Cancer Therapy, Drug Discovery Today (2016)
12. Ph-Responsive Polymer in a Core–Shell Magnetic Structure As an Efficient Carrier for Delivery of Doxorubicin to Tumor Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2018)
13. Nanohybrid Stimuli-Responsive Microgels: A New Approach in Cancer Therapy, Nanoarchitectonics for Smart Delivery and Drug Targeting (2016)
14. Redox-Sensitive Smart Nanosystems for Drug and Gene Delivery, Current Organic Chemistry (2016)
15. Fabrication Technology of Chitosan-Based Ipn: Drug Delivery Application, Interpenetrating Polymer Network: Biomedical Applications (2020)
16. Microfluidic Synthesis of Zoledronic Acid Loaded Chitosan Nanoparticles Used for Osteogenic Differentiation of Mesenchymal Cells, International Journal of Biological Macromolecules (2023)
17. Block Ionomer Micellar Nanoparticles From Double Hydrophilic Copolymers, Classifications and Promises for Delivery of Cancer Chemotherapeutics, European Journal of Pharmaceutical Sciences (2017)
18. Anti-Cancer Drug Delivery Using Carbohydrate-Based Polymers, Current Pharmaceutical Design (2017)
19. On-Chip Synthesis of Fine-Tuned Bone-Seeking Hybrid Nanoparticles, Nanomedicine (2015)
20. Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels, Carbohydrate Polymers (2020)
21. Streptomycin-Anionic Linear Globular Dendrimer G2: Novel Antibacterial and Anticancer Agents, Advances in Nano Research (2019)
22. Nanoparticles and Targeted Drug Delivery in Cancer Therapy, Immunology Letters (2017)
23. Collagenous Matrix Supported by a 3D-Printed Scaffold for Osteogenic Differentiation of Dental Pulp Cells, Dental Materials (2018)
24. Polymeric Nanoparticles for Dna Vaccine-Based Cancer Immunotherapy: A Review, Biotechnology Letters (2023)
25. Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery, Gels (2020)
26. Nexus Between in Silico and in Vivo Models to Enhance Clinical Translation of Nanomedicine, Nano Today (2021)
27. Hydrogels As Intelligent Materials: A Brief Review of Synthesis, Properties and Applications, Materials Today Chemistry (2018)
28. A Simple Coating Method of Pdms Microchip With Ptfe for Synthesis of Dexamethasone-Encapsulated Plga Nanoparticles, Drug Delivery and Translational Research (2019)
29. 3D Printing in Oral & Maxillofacial Surgery, 3D Printing in Oral & Maxillofacial Surgery (2021)
30. Infection-Resistant Mri-Visible Scaffolds for Tissue Engineering Applications, BioImpacts (2016)
31. Investigation of Host-Guest Interactions Between Polyester Dendrimers and Ibuprofen Using Density Functional Theory (Dft), Computational and Theoretical Chemistry (2020)
32. Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery (2015)
33. Graphene-Based Nanomaterials for Stimuli-Sensitive Controlled Delivery of Therapeutic Molecules, Frontiers in Bioengineering and Biotechnology (2023)
34. Nanoparticles: Novel Vehicles in Treatment of Glioblastoma, Biomedicine and Pharmacotherapy (2016)
35. Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?, Biotechnology Advances (2018)
36. Carboxymethylated Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
37. Synthesis and Evaluation of a Novel Nanosized Anionic Linear Globular Dendrimer G2-Ciprofloxacin Conjugate Against Prostate Cancer, Pakistan Journal of Pharmaceutical Sciences (2020)
38. Atomistic Computer Simulations on Multi-Loaded Pamam Dendrimers: A Comparison of Amine- and Hydroxyl-Terminated Dendrimers, Journal of Computer-Aided Molecular Design (2017)
39. Micelle-Based Nanoparticles With Stimuli-Responsive Properties for Drug Delivery, Nanotechnology Reviews (2024)
40. Synthesis and Characterization of Chitosan/Polyvinylpyrrolidone Coated Nanoporous Γ-Alumina As a Ph-Sensitive Carrier for Controlled Release of Quercetin, International Journal of Biological Macromolecules (2021)
41. Application of Nano-Based Systems for Drug Delivery and Targeting: A Review, Journal of Nanoparticle Research (2020)
42. Fluorescent Multi-Responsive Cross-Linked P(N-Isopropylacrylamide)-Based Nanocomposites for Cisplatin Delivery, Drug Development and Industrial Pharmacy (2017)
43. Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review, International Journal of Nanomedicine (2020)
44. Cross-Linked Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
45. Evaluation of Nanocarrier Targeted Drug Delivery of Capecitabine-Pamam Dendrimer Complex in a Mice Colorectal Cancer Model, Acta Medica Iranica (2016)
46. Linkers: The Key Elements for the Creation of Efficient Nanotherapeutics, Journal of Controlled Release (2018)
47. Facile Preparation and Characterization of Ph Sensitive Mt/Cmc Nanocomposite Hydrogel Beads for Propranolol Controlled Release, International Journal of Biological Macromolecules (2018)
48. Electrospun-Based Systems in Cancer Therapy, Electrospun Materials for Tissue Engineering and Biomedical Applications: Research# Design and Commercialization (2017)
49. Nimodipine-Loaded Pluronic® Block Copolymer Micelles: Preparation, Characterization, In-Vitro and In-Vivo Studies, Iranian Journal of Pharmaceutical Research (2016)
50. Encapsulation: Controlled Drug Delivery, Principles of Biomaterials Encapsulation: Volume 2 (2023)