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Protective Effects of Hydroalcoholic Extracts From an Ancient Apple Variety 'Mela Rosa Dei Monti Sibillini' Against Renal Ischemia/Reperfusion Injury in Rats Publisher Pubmed



Yousefimanesh H1, 2, 3 ; Hemmati S1 ; Shirooie S4 ; Nabavi SM5 ; Talebzadeh Bonakdar A1 ; Fayaznia R2 ; Hossein Asgardoon M6 ; Zare Dehnavi A3 ; Ghafouri M3 ; Nkuimi Wandjou JG7 ; Caprioli G7 ; Sut S8 ; Maggi F7 ; Dallacqua S9
Authors
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Authors Affiliations
  1. 1. Preclinical Core Facility, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Immunodeficiencies, Studs' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. School of Pharmacy, University of Camerino, Camerino, Italy
  8. 8. Department of Agronomy, Food, Natural Resources, Animals and Environment, University of Padova, Legnaro, Italy
  9. 9. Departement of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy

Source: Food and Function Published:2019


Abstract

The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple variety of central Italy, the 'Mela Rosa dei Monti Sibillini', on the damage caused by renal ischemia/reperfusion injury (IRI) in rats. Thirty mg per kg b.w. of the extracts were administered intraperitoneally to male adult Wistar rats 3 days before the induction of IRI by pedicle clamping. A significant decrease in the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNFα), interleukin 1 beta (IL-1β) and nuclear factor-κB (NF-κB) was observed in the groups pre-treated with APE when compared with IRI rats. The chemical composition of APE was determined by HPLC-DAD-MSn highlighting a significant amount of proanthocyanidins (52.9 mg g-1), flavonols (42.27 mg g-1) and dihydrochalcones (11.75 mg g-1). These findings indicated that this ancient apple variety is a promising source of nutraceuticals and functional foods helpful to manage complications of renal disorders. © 2019 The Royal Society of Chemistry.
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