Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane

Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane Publisher Pubmed

Fazelinejad H¹ ; Zahedi E² ; Khadivi M³

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1. Research Core of Cognitive Sciences and Aging Studies, Research Center of Hakim Sabzevari, Hakim Sabzevari University, Sabzevar, Iran
2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Biology, Payam Noor University, Tehran, 19395-4697, Iran

Source: Neuroscience Letters Published:2024

Abstract

Alzheimer's disease (AD) is a prevalent form of dementia in the elderly. There is currently no effective treatment available for this disease. Diagnosis of AD typically relies on clinical manifestations and specific biomarkers. The present study investigated the impact of inducing Alzheimer's disease (AD) in mice through the injection of lysozyme amyloids formed in the presence or absence of Bis (Indolyl) phenylmethane (BIPM) on alterations in plasma lipid profiles and liver enzyme activities. 24 adult Wistar rats were divided into control, Scopolamine, Lysozyme, BIPM groups and the blood samples were obtained from the groups for biochemical analysis. The findings of the study revealed significant changes in the plasma lipid profiles and liver enzyme markers of the Lysozyme group compared to the control group. The Lysozyme group exhibited elevated triglycerides (n = 6, P < 0.02) and LDL levels (n = 6, P < 0.02), reduced HDL (n = 6, P < 0.05) and cholesterol levels (n = 6, P < 0.02), and altered serum glutamic oxaloacetic transaminase (SGOT) level (n = 6, P < 0.05) compared to controls. While the level of serum glutamic pyruvic transaminase (SGPT) did not change significantly compared to the control. BIPM groups showed no significant changes in lipid or enzyme levels compared to controls. Overall, our research has shown that BIPM has the ability to modify the structure of HEWL aggregates, thereby improving the detrimental effects associated with AD caused by these aggregates. Analyzing lipid profiles and liver enzyme markers presents a promising avenue for targeted therapeutic approaches. These alterations observed in the plasma may potentially serve as candidate biomarkers for diagnosing this disease. © 2024 Elsevier B.V.

2. A Comprehensive Investigation of the Potential Role of Lipoproteins and Metabolite Profile As Biomarkers of Alzheimer's Disease Compared to the Known Csf Biomarkers, International Journal of Alzheimer's Disease (2023)

3. Bis(Indolyl)Phenylmethane Derivatives Are Effective Small Molecules for Inhibition of Amyloid Fibril Formation by Hen Lysozyme, European Journal of Medicinal Chemistry (2016)

4. Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity, Archives Italiennes de Biologie (2017)

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Azadeh Ebrahim-Habibi (2)

Style	Citing Format
MLA	Fazelinejad H, Zahedi E, Khadivi M. "Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane." Neuroscience Letters, vol. 833, no. , 2024, pp. -.
APA	Fazelinejad H, Zahedi E, Khadivi M (2024). Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane. Neuroscience Letters, 833(), -.
Chicago	Fazelinejad H, Zahedi E, Khadivi M. "Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane." Neuroscience Letters 833, no. (2024): -.
Harvard	Fazelinejad H, Zahedi E, Khadivi M (2024) 'Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane', Neuroscience Letters, 833(), pp. -.
Vancouver	Fazelinejad H, Zahedi E, Khadivi M. Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane. Neuroscience Letters. 2024;833():-.
BibTex	@article{ author = {Fazelinejad H and Zahedi E and Khadivi M}, title = {Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane}, journal = {Neuroscience Letters}, volume = {833}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Fazelinejad H AU - Zahedi E AU - Khadivi M TI - Altering Plasma Lipids and Liver Enzyme Activities Via Hippocampal Injections of Hen Lysozyme Amyloid Aggregates in an Alzheimer's Disease Mouse Model: Insights Into the Therapeutic Role of Bis (Indolyl) Phenylmethane JO - Neuroscience Letters VL - 833 IS - SP - EP - PY - 2024 ER -

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