Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples

Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples Publisher

Khoubnasabjafari M¹ ; Samadi A² ; Jouyban A^{2, 3}

Show Affiliations

1. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Microchemical Journal Published:2020

Abstract

A rapid, accurate and precise spectrophotometric procedure was described for in situ quantification of phenytoin (PHT) using graphene quantum dots (GQD) stabilized on gold nanoparticles. It was achieved by synchronization of the GQD-gold nanoparticles synthesis and analyte determination via simple mixing PHT, as-prepared GQD obtained by direct pyrolysis of citric acid and HAuCl4 within 30 min at room temperature. The X-ray diffraction patterns and Fourier transform infrared spectroscopy clearly confirmed the graphene honeycomb lattice of the graphene in nanoscale structure of gold nanoparticles. In addition, transmission electron microscopy, fluorescence, and ultraviolet–visible spectroscopies revealed the mechanism of aggregation of GQD supported gold nanoparticles for the detection of PHT. The proposed colorimetric assay is able to determine concentrations of PHT in the range of 0.01–0.20 µg·mL−1 with a low limit of detection (5 ng·mL−1) in human plasma obtained from patients taking PHT. © 2020 Elsevier B.V.

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Style	Citing Format
MLA	Khoubnasabjafari M, Samadi A, Jouyban A. "Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples." Microchemical Journal, vol. 159, no. , 2020, pp. -.
APA	Khoubnasabjafari M, Samadi A, Jouyban A (2020). Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples. Microchemical Journal, 159(), -.
Chicago	Khoubnasabjafari M, Samadi A, Jouyban A. "Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples." Microchemical Journal 159, no. (2020): -.
Harvard	Khoubnasabjafari M, Samadi A, Jouyban A (2020) 'Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples', Microchemical Journal, 159(), pp. -.
Vancouver	Khoubnasabjafari M, Samadi A, Jouyban A. Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples. Microchemical Journal. 2020;159():-.
BibTex	@article{ author = {Khoubnasabjafari M and Samadi A and Jouyban A}, title = {Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples}, journal = {Microchemical Journal}, volume = {159}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Khoubnasabjafari M AU - Samadi A AU - Jouyban A TI - Graphene Quantum Dot-Stabilized Gold Nanoparticles As a New Colorimetric Probe for in Situ Quantification of Phenytoin in Biological Samples JO - Microchemical Journal VL - 159 IS - SP - EP - PY - 2020 ER -

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