Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Highly Sensitive Determination of Theophylline Based on Graphene Quantum Dots Modified Electrode Publisher



Ganjali MR1, 2 ; Dourandish Z3 ; Beitollahi H4 ; Tajik S5 ; Hajiaghababaei L6 ; Larijani B7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran
  4. 4. Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
  5. 5. Bam University of Medical Sciences, Bam, Iran
  6. 6. Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran
  7. 7. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Electrochemical Science Published:2018


Abstract

In this study we introduce a novel modification for the surface of screen-printed electrode (SPE) by graphene quantum dot (GQD) in order to be used in the determination and detection of theophylline. An uncomplicated technique was employed to stabilize GQD on screen-printed electrode. Function evaluation of the GQD modified SPE (GQD/SPE) by cyclic voltammetry revealed enhanced electroactivity in the oxidation of theophylline in buffer solution of phosphate. Differential-pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry were applied to determine the sensitivity of GQD/SPE toward detection of theophylline. A wide linear concentration range of 1.0-700.0 μM and detection limit of 0.2 μM (S/N = 3) obtained under optimized conditions. This sensor was successful in the assessment of theophylline in real samples. © 2018 The Authors.