Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity

Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity Publisher Pubmed

Ramshini H¹ ; Moghaddasi AS¹ ; Aldaghi LS² ; Mollania N³ ; Ebrahimhabibi A⁴

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1. Department of Biology, Payam Noor University, Tehran, Iran
2. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
3. Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran
4. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives Italiennes de Biologie Published:2017

Abstract

Alzheimer's disease (AD) is a chronic degenerative disease characterized by the presence of amyloid plaques and neurofibrillary tangles (NFTs), which results into memory and learning impairments. In the present study, we showed that the aggregates formed by a protein that has no link with Alzheimer's disease, namely the hen egg white lysozyme (HEWL), were cytotoxic and decreased spatial learning and memory in rats. The effect of Ag-nano particles (Ag-NPs) was investigated on disruption of amyloid aggregation and preservation of cognitive behavior of rats. Twenty-four male Wistar rats were divided into 4 groups including a control group, and injected with either scopolamine, lysozyme or aggregates pre-incubated with Ag-NPs. Rats' behavior was monitored using Morris water maze (MWM) twenty days after injections. HEWL aggregation in the presence and absence of the Ag-NPs was assayed by Thioflavin T binding, atomic force microscopy and cell-based cytotoxicity assay. Ag-NPs were capable to directly disrupt HEWL oligomerization and the resulting aggregates were non-toxic. We also showed that rats of the Ag-NPs group found MWM test platform in less time and with less distance traveled, in comparison with lysozyme group. Ag-NPs also increased the percentage of time elapsed and the distance swum in the target quadrant in the rat model of AD, in probe test. These observations suggest that Ag-NPs improved spatial learning and memory by inhibiting amyloid fibril-induced neurotoxicity. Furthermore, we suggest using model proteins as a valid tool to investigate the pathogenesis of Alzheimer's disease.

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Azadeh Ebrahim-Habibi (4)

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Style	Citing Format
MLA	Ramshini H, et al.. "Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity." Archives Italiennes de Biologie, vol. 155, no. 3, 2017, pp. 131-141.
APA	Ramshini H, Moghaddasi AS, Aldaghi LS, Mollania N, Ebrahimhabibi A (2017). Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity. Archives Italiennes de Biologie, 155(3), 131-141.
Chicago	Ramshini H, Moghaddasi AS, Aldaghi LS, Mollania N, Ebrahimhabibi A. "Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity." Archives Italiennes de Biologie 155, no. 3 (2017): 131-141.
Harvard	Ramshini H et al. (2017) 'Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity', Archives Italiennes de Biologie, 155(3), pp. 131-141.
Vancouver	Ramshini H, Moghaddasi AS, Aldaghi LS, Mollania N, Ebrahimhabibi A. Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity. Archives Italiennes de Biologie. 2017;155(3):131-141.
BibTex	@article{ author = {Ramshini H and Moghaddasi AS and Aldaghi LS and Mollania N and Ebrahimhabibi A}, title = {Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity}, journal = {Archives Italiennes de Biologie}, volume = {155}, number = {3}, pages = {131-141}, year = {2017} }
RIS	TY - JOUR AU - Ramshini H AU - Moghaddasi AS AU - Aldaghi LS AU - Mollania N AU - Ebrahimhabibi A TI - Silver Nano Particles Ameliorate Learning and Spatial Memory of Male Wistar Rats by Prevention of Amyloid Fibril-Induced Neurotoxicity JO - Archives Italiennes de Biologie VL - 155 IS - 3 SP - 131 EP - 141 PY - 2017 ER -

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