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Serum Uric Acid and Parkinson's Disease: A Systematic Review and Meta-Analysis Publisher



Balabandian M1, 2 ; Salahi S3 ; Mahmoudvand B2 ; Esmaeilzadeh M4 ; Hashemi SM5 ; Nabizadeh F1, 2
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Minimally Invasive Surgery Research Center, Tehran, Iran
  4. 4. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Neurology and Clinical Neuroscience Published:2023


Abstract

Background: Numerous studies attempted to fully understand the association between serum uric acid (UA) and Parkinson's disease. Due to the contradictory results, we aimed to perform a systematic review and meta-analysis to investigate the association between UA and PD. Methods: We conducted a literature search in the electronic databases: PubMed, Web of Science, and Scopus. We included all studies comparing serum uric acid in PD patients and control subjects. Results: After the screening, 30 studies met our inclusion criteria and entered our systematic review and meta-analysis. The mean difference (MD) of UA between PD and control using a random-effect model was −00.49 (95% CI −0.65, −0.33). Conclusion: Our results suggests that serum levels of UA are significantly lower in patients with PD than in healthy subjects. However, further studies are needed to clarify the association of geographic region, PD progression, and PD treatment with UA serum levels. © 2023 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
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