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The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy Against Oral Infections Publisher



Afrasiabi S1 ; Partoazar A2 ; Chiniforush N1 ; Goudarzi R3
Authors
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Authors Affiliations
  1. 1. Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, 1441987566, Iran
  2. 2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, 1441987566, Iran
  3. 3. Division of Research and Development, Pharmin USA, LLC, San Jose, 95128, CA, United States

Source: Pharmaceuticals Published:2022


Abstract

Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, chlorella, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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