A Rare Case of Candida Albicans-Associated Meningitis; a Case Report Study Publisher



Askari S¹ ; Monajati M¹ ; Erfani S² ; Lashkarbolouk N³ ; Hosseini SS^{2, 4}
Source: Clinical Infection in Practice Published:2025

Abstract

Background: Fungal infections of the Central Nervous System (CNS) are rare but can have devastating consequences. In immunocompromised patients, such as those on chronic dexamethasone therapy, Candida can invade the bloodstream and enter the CNS, causing meningitis. Diagnosis of fungal infections often relies on pathogen culture, which is time-consuming and insensitive. Case presentation: we present a 60-year-old female with chronic use of dexamethasone, with Candida albicans-associated meningitis, diagnosed using phenotyping, genotyping, and sequencing methods. Unfortunately, her condition deteriorated despite antifungal therapy, and she eventually succumbed to severe sepsis and septic shock. Conclusion: Physicians must remain vigilant regarding fungal infections, particularly those affecting the brain, in immunosuppressed patients. Prompt diagnosis and the early treatment is crucial in preventing adverse outcomes. The efficacy of treatment may differ based on the infection's severity and the patient's immune status, making the early identification of clinical deterioration vital for effective management and prognosis. © 2025