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Mixinyeast: A Multicenter Study on Mixed Yeast Infections Publisher



Medina N1 ; Sotodebran JC1 ; Seidel D2, 3, 4 ; Akyar I5, 6 ; Badali H7 ; Barac A8 ; Bretagne S9, 10 ; Cag Y11, 12 ; Cassagne C13 ; Castro C14 ; Chakrabarti A15 ; Dannaoui E16 ; Cardozo C17 ; Garciarodriguez J18 Show All Authors
Authors
  1. Medina N1
  2. Sotodebran JC1
  3. Seidel D2, 3, 4
  4. Akyar I5, 6
  5. Badali H7
  6. Barac A8
  7. Bretagne S9, 10
  8. Cag Y11, 12
  9. Cassagne C13
  10. Castro C14
  11. Chakrabarti A15
  12. Dannaoui E16
  13. Cardozo C17
  14. Garciarodriguez J18
  15. Guitard J19
  16. Hamal P20
  17. Hoenigl M21
  18. Jagielski T22
  19. Khodavaisy S23
  20. Lo Cascio G24
  21. Martinezrubio MC25
  22. Meletiadis J26
  23. Munoz P27, 28
  24. Ochman E29
  25. Pelaez T30
  26. Balzola APA31
  27. Prattes J32
  28. Roilides E33
  29. De Pipaon MRP34
  30. Stauf R35, 36
  31. Steinmann J35, 36
  32. Suarezbarrenechea AI37
  33. Tejero R38
  34. Trovato L39, 40
  35. Vinuela L41
  36. Wongsuk T42
  37. Zak I43
  38. Zarrinfar H44
  39. Lassflorl C45
  40. Arikanakdagli S46
  41. Alastrueyizquierdo A1
Show Affiliations
Authors Affiliations
  1. 1. Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, 28220, Spain
  2. 2. Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Department I of Internal Medicine, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, 50937, Germany
  3. 3. European Diamond Excellence Center for Medical Mycology, European Confederation of Medical Mycology (ECMM), Cologne, 50937, Germany
  4. 4. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany
  5. 5. Department of Medical Microbiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, 34758, Turkey
  6. 6. Acibadem Labmed Laboratories, Istanbul, 34752, Turkey
  7. 7. Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, 48157-33971, Iran
  8. 8. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, 11000, Serbia
  9. 9. Laboratoire de Parasitologie-Mycologie, Hopital Saint-Louis, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, 75010, France
  10. 10. Department of Infectious Agents, Universite de Paris, Paris, 75006, France
  11. 11. Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, 34722, Turkey
  12. 12. Department of Infectious Diseases and Clinical Microbiology, Istanbul Medeniyet University School of Medicine, Istanbul, 34093, Turkey
  13. 13. Aix-Marseille University, UMR MD3 IP-TPT, Marseilles, 13885, France
  14. 14. Microbiology Service, Clinical Unit of Infectious Diseases and Microbiology, Hospital Universitario Valme, Sevilla, 41014, Spain
  15. 15. Department of Medical Microbiology, Institute of Medical Education and Research, Chandigarh, 160012, India
  16. 16. Unite de Parasitologie-Mycologie, Service de Microbiologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP), Universite de Paris, Paris, 75015, France
  17. 17. Hospital Universitario Clinic, Barcelona, 08036, Spain
  18. 18. Hospital Universitario La Paz, Madrid, 28046, Spain
  19. 19. Service de Parasitologie-Mycologie, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hopital Saint-Antoine, Sorbonne Universite, Inserm, Paris, 75012, France
  20. 20. Department of Microbiology, Palacky University, Faculty of Medicine and Dentistry and University Hospital, Olomouc, 775 15, Czech Republic
  21. 21. Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, 92093, CA, United States
  22. 22. Department of Medical Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, I. Miecznikowa 1, Warsaw, 02-096, Poland
  23. 23. Division of Molecular Biology, Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14167-53955, Iran
  24. 24. Microbiology and Virology Unit, Department of Pathology and Diagnostic, Azienda Ospedaliera Universitaria Integrata, Verona, 30126, Italy
  25. 25. Hospital Universitario de Puerto Real, Cadiz, 11510, Spain
  26. 26. Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Haidari, Athens, 12462, Greece
  27. 27. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Maranon, Madrid, 28007, Spain
  28. 28. Department of Medicine, Universidad Complutense de Madrid, CIBERES (CB06/06/0058), Madrid, 28040, Spain
  29. 29. Department of Clinical Microbiology, The Maria Sklodowska-Curie Institute of Oncology, W. K. Roentgena 5, Warsaw, 02-781, Poland
  30. 30. Hospital Universitario Central de Asturias (HUCA), Fundacion para la Investigacion Biomedica y la Innovacion Biosanitaria del Principado de Asturias (FINBA), 33011, Asturias, Spain
  31. 31. Microbiology Department, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain
  32. 32. Section of Infectious Diseases and Tropical Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria
  33. 33. Infectious Diseases Unit, 3rd Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration General Hospital, Thessaloniki, 54642, Greece
  34. 34. Department of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen del Rocio, Seville, 41013, Spain
  35. 35. Institute of Clinical Hygiene, Medical Microbiology and Infectiology, Klinikum Nurnberg, Paracelsus Medical University, Nuremberg, 90419, Germany
  36. 36. Institute of Medical Microbiology, University Hospital Essen, Essen, 45122, Germany
  37. 37. Infectious disease and Clinical Microbiology Department, Virgen Macarena University Hospital, Sevilla, 41009, Spain
  38. 38. Unit of Microbiology, Hospital Universitario Reina Sofia, Cordoba, 14004, Spain
  39. 39. U.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-Vittorio Emanuele�, Catania, 95123, Italy
  40. 40. Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, 95123, Italy
  41. 41. Servicio de Microbiologia Hospital Universitario Rio Hortega, Valladolid, 47012, Spain
  42. 42. Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, 10300, Thailand
  43. 43. Department of Clinical Microbiology, Children’s University Hospital of Cracow, Krakow, 30-663, Poland
  44. 44. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, 91766-99199, Iran
  45. 45. Department of Hygiene und Medical Microbiology, Medical University of Innsbruck, Innsbruck, 6020, Austria
  46. 46. Department of Medical Microbiology, Hacettepe University Medical School, Ankara, 06100, Turkey

Source: Journal of Fungi Published:2021


Abstract

Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epi-demiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe ac-counted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions. © 2020 by the authors. Li-censee MDPI, Basel, Switzerland.
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