Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery

Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery Publisher Pubmed

Manayi A¹ ; Nikan M¹ ; Nobakhthaghighi N² ; Abdollahi M^{3, 4, 5}

Show Affiliations

1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Cyprus
3. Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
4. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Mersin 10, Turkey

Source: Current Medicinal Chemistry Published:2018

Abstract

Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound. Nano-drug delivery systems may improve the pharmacokinetic, bioavailability, and therapeutic activity of some medicines. The present review has focused on recent developments regarding nano-drug delivery systems of ursolic acid in cancer therapy. © 2018 Bentham Science Publishers.

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Mohammad Abdollahi (6)

Alireza Vatanara (3)

Style	Citing Format
MLA	Manayi A, et al.. "Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery." Current Medicinal Chemistry, vol. 25, no. 37, 2018, pp. 4866-4875.
APA	Manayi A, Nikan M, Nobakhthaghighi N, Abdollahi M (2018). Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery. Current Medicinal Chemistry, 25(37), 4866-4875.
Chicago	Manayi A, Nikan M, Nobakhthaghighi N, Abdollahi M. "Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery." Current Medicinal Chemistry 25, no. 37 (2018): 4866-4875.
Harvard	Manayi A et al. (2018) 'Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery', Current Medicinal Chemistry, 25(37), pp. 4866-4875.
Vancouver	Manayi A, Nikan M, Nobakhthaghighi N, Abdollahi M. Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery. Current Medicinal Chemistry. 2018;25(37):4866-4875.
BibTex	@article{ author = {Manayi A and Nikan M and Nobakhthaghighi N and Abdollahi M}, title = {Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery}, journal = {Current Medicinal Chemistry}, volume = {25}, number = {37}, pages = {4866-4875}, year = {2018} }
RIS	TY - JOUR AU - Manayi A AU - Nikan M AU - Nobakhthaghighi N AU - Abdollahi M TI - Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery JO - Current Medicinal Chemistry VL - 25 IS - 37 SP - 4866 EP - 4875 PY - 2018 ER -

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