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Preparation and Characterization of 3D Nanocomposite Scaffold From Bioactive Glass/Β-Tricalcium Phosphate Via Robocasting Method for Bone Tissue Engineering Publisher



Monfared MH1 ; Ranjbar FE2 ; Torbati M3 ; Ali Poursamar S4 ; Lotfibakhshaiesh N1 ; Ai J1 ; Ebrahimibarough S1 ; Azami M1
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Authors Affiliations
  1. 1. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Molecular Medicine Research Center, Research institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  3. 3. Abtin Teb Fanavar Co, Dental Equipment and Biomaterials Incubation Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Biomaterials, Nanotechnology, and Tissue Engineering Group, Advanced Medical Technology Department, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Non-Crystalline Solids Published:2022


Abstract

In this research, a three-dimensional 45S5 bioactive glass (BG) /β-tricalcium phosphate (TCP) composite (50/50 wt.%) scaffold was prepared by the Robocasting method. For this aim, BG and TCP were synthesized via sol-gel and precipitation methods, respectively, and characterized. The scaffolds were robocast by extruding the ink composed of a proper amount of BG, TCP, and required additives, then, characterized in terms of physicochemical and biological properties. Results showed that nano BG and TCP were synthesized successfully. Scaffold characterization showed that the scaffold had a controlled and interconnected porosity (40%) that exhibited notable average mechanical strength (∼17.39MP) as well as good bioactivity and supported the attachment and the proliferation of mesenchymal stem cells and had a limited effect on the survival of these cells. According to the results, it is concluded that using the Robocasting method for preparing BG/TCP scaffold provided a 3D porous interconnected structure with notable mechanical strength © 2022
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