Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Link-A Long Non-Coding Rna and Vegf Rna Expression in Epithelial Ovarian Cancer Patients Publisher Pubmed



Maleki P1 ; Sheida SV2 ; Mowla SJ2 ; Soleimani V3 ; Taheri M4 ; Raheb J1
Authors
Show Affiliations
Authors Affiliations
  1. 1. National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  2. 2. Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Pathology Department, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
  4. 4. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Human Antibodies Published:2020


Abstract

LINK-A (long intergenic non-coding RNA for kinase activation) is a newly identified long non-coding RNA with oncogenic function, which leads to the hyperactivation of AKT and HIF1α. thereby, fosters cell proliferation, mobility and metastasis. VEGF (vascular endothelial growth factor), a well-known cytokine has an important role in angiogenesis. In this study, we quantified RNA expression of LINK-A and VEGF on 45 tumor specimens obtained from Iranian patients diagnosed with Epithelial Ovarian Cancer (EOC). Our goal was to evaluate expression of LINK-A lncRNA and VEGF mRNA in ovarian cancer tissues and find the probable correlation of LINK-A with VEGF as a major transcription target for HIF1α. LINK-A and VEGF were remarkably overexpressed in EOC tissues compared to normal tissues (P value: 0.004, 0.0001, respectively), but we did not find correlation between LINK-A and VEGF RNA expressions in this study. LINK-A was significantly overexpressed in higher stages of cancer and tumor grades. VEGF was only significantly elevated in higher stages. This study confirms importance of novel lncRNA of LINK-A in Iranian EOC patients. © 2020 - IOS Press and the authors. All rights reserved.
Related Docs
1. Overexpression of Long Intergenic Noncoding Rnas in Bladder Cancer: A New Insight to Cancer Diagnosis, Pathology Research and Practice (2022)
2. Ovarian Cancer in the World: Epidemiology and Risk Factors, International Journal of Women's Health (2019)
3. Long Non-Coding Rna As a Novel Biomarker and Therapeutic Target in Aggressive B-Cell Non-Hodgkin Lymphoma: A Systematic Review, Journal of Cellular and Molecular Medicine (2023)
4. Lncrnas Roles in Chemoresistance of Cancer Cells, Current Molecular Medicine (2022)
5. The Association Between Oral Contraceptive Pills and Ovarian Cancer Risk: A Systematic Review and Meta-Analysis; [Association Entre Pilules Contraceptives Orales Et Risque De Cancer De L'ovaire: Une Revue Systematique Et Une Meta-Analyse], Bulletin du Cancer (2024)