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The Role of Long Noncoding Rnas (Lncrnas) in the Pathogenesis of Chemoresistance in Endometrial Cancer: A Molecular Approach and Future Perspective Publisher



Lorestani K1 ; Esgandari M2 ; Ghorbanzade S3 ; Ghezelsofla M4 ; Etezadi A5 ; Mehrabinia M6 ; Hasanvand A7, 8 ; Khodakarim N9 ; Rahimi S10
Authors
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Authors Affiliations
  1. 1. Department of Gynecology and Obstructive, Lorestan University of Medical Science, Khorramabad, Iran
  2. 2. Department of Gynecology and Obstructive, Shahid Beheshti University of Medical Science, Tehran, Iran
  3. 3. Department of Gynecology and Obstructive, Iran University of Medical Science, Tehran, Iran
  4. 4. Tehran University of Medical Science, Tehran, Iran
  5. 5. Reproductive Health Research Center, Department of Obstetrics & Gynecology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
  6. 6. Department of Medical Laboratory Science, Faculty of Paramedicine, Ahvaz Jundishapour of Medical Sciences, Ahvaz, Iran
  7. 7. Department of General Surgery, Lorestan University of Medical Science, Khorramabad, Iran
  8. 8. Student Reseach Committee, Lorestan University of Medical Science, Khorramabad, Iran
  9. 9. Department of Internal Medicine, School of Medicine, Hazrat-E Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Gynecology and Obstructive, Qazvin University of Medical Science, Qazvin, Iran

Source: Indian Journal of Gynecologic Oncology Published:2025


Abstract

Aim: Endometrial cancer (EC) is one of the common diseases that affects women. In an advanced state, malignant cells become resistant to chemotherapy, reducing patients' survival. Long noncoding RNAs (LncRNAs) are one of the factors contributing to chemotherapy resistance. This review investigates the role of LncRNAs in the processes of proliferation, apoptosis, angiogenesis, and epithelial–mesenchymal transition (EMT). Method: In this review study, the article with English language was selected for writing the manuscript. Also, the PubMed database was used for search. Result: LncRNAs cause chemoresistance by regulating genes and molecular pathways. These genes and pathways are mainly involved in the processes of apoptosis, proliferation, EMT, and angiogenesis. These processes cause the insensitivity of malignant cells to chemotherapy drugs and the occurrence of chemoresistance. Conclusion: Given the dual role of some LncRNAs, identifying the pathways associated with LncRNAs, as well as their UP and Downstream factors can be effective in designing targeted therapies such as personalizing medicine. © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024.