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Heparin and Related Drugs for Venous Thromboembolism Prophylaxis: Subcutaneous or Intravenous Continuous Infusion? Publisher Pubmed



Izadpanah M1 ; Khalili H1 ; Dashtikhavidaki S1 ; Mohammadi M2
Authors
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Authors Affiliations
  1. 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14155/6451, Tehran, 1417614411, Iran
  2. 2. Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Comparative Effectiveness Research Published:2015


Abstract

In this article, the most evidenced approaches of unfractionated heparin administration for prevention of venous thromboembolism in medical and surgical hospitalized patients will be reviewed. Present data were collected by searching Scopus, PubMed, MEDLINE, Science direct, Clinical trials and Cochrane database systematic reviews. Subcutaneous low doses of unfractionated heparin (10000-15000 IU) in two or three divided doses per day are commonly administrated for venous thromboembolism prevention in different medical and surgical populations. In some populations such as obese surgical and critically ill patients, due to altered pharmacokinetics behavior of unfractionated heparin, continuous intravenous infusion of the low doses of unfractionated heparin has been proposed. © 2015 Future Medicine Ltd.