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Evaluation of Sudden Sensory-Neural Hearing Loss Patients Treated With Systemic Steroids With Additional Intratympanic Dexamethasone Injection in Different Intervals; a Clinical Trial Study Publisher



Nourizadeh N1 ; Rezaiee N1 ; Rajati M1 ; Dabiri S2 ; Afzalzadeh MR1 ; Hasanabadi K3
Authors
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Authors Affiliations
  1. 1. Sinus and Surgical Endoscopic Research Center, Department of Otorhinolaryngology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9176717671, Iran
  2. 2. Otolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Mashhad University of Medical Sciences, Mashhad, Iran

Source: Indian Journal of Otolaryngology and Head and Neck Surgery Published:2023


Abstract

Sudden Sensory-Neural Hearing Loss (SSNHL) is one of the most important otologic emergency. Although adding intratympanic (IT) steroids to systematic steroid may be beneficial, the exact timing of the IT injections to provide the best response needs further investigations. To compare different protocols in treting sudden sensorineural hearing loss. We performed a clinical trial study on 120 patients from October 2021 to February 2022. All patients were prescribed 1 mg/Kg daily oral prednisolone. After randomization to three groups, the control group received standard twice a week IT steroid injections in 12 days (four total injections) while intervention groups 1 and 2 received once and twice a day IT injections for ten days. Audiometric study repeated 10–14 days after the last injection and assessed based on the Siegel criteria. We used the Chi-Square, Analysis of Variance (ANOVA), Kruskal–Wallis’s tests where appropriate. The most clinical improvement was found in the standard treatment group, and group-2 had the greatest number of patients with no improvement; however, no overall significant difference was observed among the three groups (p-value: 0.066; Pearson Chi-Square). Less frequent IT injections in patients already on systemic steroids provide similar results to more frequent injections. © 2023, Association of Otolaryngologists of India.