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Heart Valve Tissue Engineering: An Overview of Heart Valve Decellularization Processes Publisher Pubmed



Boroumand S1 ; Asadpour S2 ; Akbarzadeh A3 ; Faridimajidi R1 ; Ghanbari H1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

Source: Regenerative Medicine Published:2018


Abstract

Despite recent advances in medicine and surgery, many people still suffer from cardiovascular diseases, which affect their life span and morbidity. Regenerative medicine and tissue engineering are novel approaches based on restoring or replacing injured tissues and organs with scaffolds, cells and growth factors. Scaffolds are acquired from two major sources, synthetic materials and naturally derived scaffolds. Biological scaffolds derived from native tissues and cell-derived matrix offer many advantages. They are more biocompatible with a higher affinity to cells, which facilitate tissue reconstruction. Interestingly, xenogeneic recipients generally tolerate their components. Therefore, heart valve tissue engineering is increasingly benefiting from naturally derived scaffolds. In this review, we investigated the different protocols and methods that have been used for heart valve decellularization. © 2018 Future Medicine Ltd.
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