Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nanofibrous Bioengineered Heart Valve—Application in Paediatric Medicine Publisher Pubmed



Namdari M1 ; Eatemadi A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Cardiology, Lorestan University of Medical Sciences, Khoramabad, Iran
  2. 2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2016


Abstract

Heart valves are currently under thorough investigation in tissue engineering (TE) research. Mechanical and biological heart valve prostheses which are recently used have several shortcomings. While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation. Mechanical prostheses on the other hand are based on metallic, carbon, and polymeric components, and require continuous treatment with anticoagulant, which result in adverse reactions, e.g. endocarditis and thromboembolic complications. Therefore, there has been efforts to synthesize bioartificial heart valve using bioengineering. The resulting product must be durable with appropriate mechanical properties, biocompatible, and have the ability to grow. Diseased heart valves replacement by surgery is now common, this enhances quality of life and survival for many patients. The center of attraction of recent methods in regenerative medicine are based on the restoration of pathologically altered tissue architectures by cells transplantation in combination with supportive scaffolds, and growth factors. We propose that nanofiber scaffold for paediatric Tissue Engineered Heart Valve (TEHV) will meet most of these requirements, particularly those related to somatic growth, in addition, as the nanofiber scaffold is eroded and new valve is formed, the valve develops in the child until adulthood. © 2016 Elsevier Masson SAS
Related Docs
View other Related Docs
1. Paediatric Nanofibrous Bioprosthetic Heart Valve, IET Nanobiotechnology (2017)
2. Recent Advances in Cardiac Regeneration: Stem Cell, Biomaterial and Growth Factors, Biomedicine and Pharmacotherapy (2017)
3. A Brief Review on the Application of Nanoparticle Enclosed Herbal Medicine for the Treatment of Infective Endocarditis, Biomedicine and Pharmacotherapy (2017)
4. Nanoliposome Encapsulated Anesthetics for Local Anesthesia Application, Biomedicine and Pharmacotherapy (2017)
5. Heart Targeted Nanoliposomal/Nanoparticles Drug Delivery: An Updated Review, Biomedicine and Pharmacotherapy (2017)
6. Phyto-Anesthetics: A Mini-Review on Herb–Anesthesia Drug Interactions, Biomedicine and Pharmacotherapy (2016)
7. Stem Cell Therapies for Congenital Heart Disease, Biomedicine and Pharmacotherapy (2016)
8. Synthesis and Characterization of Chrysin-Loaded Pcl-Peg-Pcl Nanoparticle and Its Effect on Breast Cancer Cell Line, Biomedicine and Pharmacotherapy (2016)
Experts (# of related papers)
View all Related Experts
Ali Etemadi (20)
Babak Negahdari (13)
Other Related Docs
9. Colon Cancer Targeting Using Conjugates Biomaterial 5-Flurouracil, Biomedicine and Pharmacotherapy (2016)
10. Magnetic Nanogel Polymer of Bupivacaine for Ankle Block in Rats, Journal of Microencapsulation (2016)
11. Natriuretic Peptides and Their Therapeutic Potential in Heart Failure Treatment: An Updated Review, Cellular and Molecular Biology (2016)
12. Application of Stem Cell for the Regeneration of Spiral Ganglion Neurons, Cellular and Molecular Biology (2017)
13. Effects of Anesthetic and Analgesic Techniques on Cancer Metastasis, Biomedicine and Pharmacotherapy (2017)
14. Recent Advances in Silicon Nanowire Biosensors: Synthesis Methods, Properties, and Applications, Nanoscale Research Letters (2016)
15. Inner Ear Drug Delivery Using Liposomes, Cellular and Molecular Biology (2017)
16. Cardioprotective Effects of Curcumin-Loaded Magnetic Hydrogel Nanocomposite (Nanocurcumin) Against Doxorubicin-Induced Cardiac Toxicity in Rat Cardiomyocyte Cell Lines, Artificial Cells# Nanomedicine and Biotechnology (2017)
17. Synthesis, Properties and Biomedical Applications of Carbon-Based Quantum Dots: An Updated Review, Biomedicine and Pharmacotherapy (2017)
18. Drug Anesthesia for Children Undergoing Magnetic Resonance Imaging: A Review, Biomedicine and Pharmacotherapy (2017)
19. Recent Advances in Magnetoliposome for Heart Drug Delivery, Artificial Cells# Nanomedicine and Biotechnology (2017)
20. Investigation of Properties of Chemically Cross-Linked Silk Nanofibrous Mat As a Nerve Guide, Materials Technology (2017)
21. New Updates Pertaining to Drug Delivery of Local Anesthetics in Particular Bupivacaine Using Lipid Nanoparticles, Nanoscale Research Letters (2016)
22. Cardioprotective Effect of Magnetic Hydrogel Nanocomposite Loaded N,Α-L-Rhamnopyranosyl Vincosamide Isolated From Moringa Oleifera Leaves Against Doxorubicin-Induced Cardiac Toxicity in Rats: In Vitro and in Vivo Studies, Journal of Microencapsulation (2017)
23. Application of Electrospun Nanofibrous Phbv Scaffold in Neural Graft and Regeneration: A Mini-Review, Nanomedicine Research Journal (2016)
24. Stem Cell, Biomaterials and Growth Factors Therapy for Hepatocellular Carcinoma, Biomedicine and Pharmacotherapy (2017)
25. Heart Valve Tissue Engineering: An Overview of Heart Valve Decellularization Processes, Regenerative Medicine (2018)
26. In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration, Artificial Cells# Nanomedicine and Biotechnology (2018)
27. Biodegradable Functional Macromolecules As Promising Scaffolds for Cardiac Tissue Engineering, Polymers for Advanced Technologies (2022)
28. Synthesis and Evaluation of Multi-Wall Carbon Nanotube-Paclitaxel Complex As an Anti-Cancer Agent, Gastroenterology and Hepatology from Bed to Bench (2016)
29. 3D Bio-Printing Technology for Body Tissues and Organs Regeneration, Journal of Medical Engineering and Technology (2018)
30. Electrospun Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Hydroxyapatite Scaffold With Unrestricted Somatic Stem Cells for Bone Regeneration, ASAIO Journal (2015)
31. Engineering Natural Heart Valves: Possibilities and Challenges, Journal of Tissue Engineering and Regenerative Medicine (2017)
32. Nanoengineered Biomaterials for Diaphragm Regeneration, Nanoengineered Biomaterials for Regenerative Medicine (2018)
33. Polyurethane/Gelatin Nanofibrils Neural Guidance Conduit Containing Platelet-Rich Plasma and Melatonin for Transplantation of Schwann Cells, Cellular and Molecular Neurobiology (2018)
34. Solvent Effect in Phase Separation for Fabrication of Micropatterned Porous Scaffold Sheets, International Journal of Polymeric Materials and Polymeric Biomaterials (2016)
35. Integration of Polysaccharide Electrospun Nanofibers With Microneedle Arrays Promotes Wound Regeneration: A Review, International Journal of Biological Macromolecules (2024)
36. Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat As Awound Healing Material, Nano Biomedicine and Engineering (2020)
37. Human Unrestricted Somatic Stem Cells Loaded in Nanofibrous Pcl Scaffold and Their Healing Effect on Skin Defects, Artificial Cells# Nanomedicine and Biotechnology (2016)
38. Electrospun Triple-Layered Plla/Gelatin. Prgf/Plla Scaffold Induces Fibroblast Migration, Journal of Cellular Biochemistry (2019)
39. The Effect of the Carbodiimide Cross-Linker on the Structural and Biocompatibility Properties of Collagen–Chondroitin Sulfate Electrospun Mat, International Journal of Nanomedicine (2018)
40. Egg Shell-Derived Calcium Phosphate/Carbon Dot Nanofibrous Scaffolds for Bone Tissue Engineering: Fabrication and Characterization, Materials Science and Engineering C (2019)
41. Electrospun Mat With Eyelid Fat-Derived Stem Cells As a Scaffold for Ocular Epithelial Regeneration, Artificial Cells# Nanomedicine and Biotechnology (2017)
42. Bone Reconstruction in Rat Calvarial Defects by Chitosan/Hydroxyapatite Nanoparticles Scaffold Loaded With Unrestricted Somatic Stem Cells, Artificial Cells# Nanomedicine and Biotechnology (2015)
43. Sophisticated Polycaprolactone/Gelatin Nanofibrous Nerve Guided Conduit Containing Platelet-Rich Plasma and Citicoline for Peripheral Nerve Regeneration: In Vitro and in Vivo Study, International Journal of Biological Macromolecules (2020)
44. Fabrication and Characterization of Nanofibrous Tricuspid Valve Scaffold Based on Polyurethane for Heart Valve Tissue Engineering, Nanomedicine Research Journal (2017)
45. Chitosan Based Extruded Nanofibrous Bioscaffold for Local Delivery Of Mesenchymal Stem Cells To Improve Diabetic Wound Healing, Stem Cell Research and Therapy (2024)
46. Bioinspired Nanofiber Scaffold for Differentiating Bone Marrow-Derived Neural Stem Cells to Oligodendrocyte-Like Cells: Design, Fabrication, and Characterization, International Journal of Nanomedicine (2020)
47. Fabrication and Characterization of Nanofibrous Poly (L-Lactic Acid)/Chitosan-Based Scaffold by Liquid–Liquid Phase Separation Technique for Nerve Tissue Engineering, Molecular Biotechnology (2021)
48. Unrestricted Somatic Stem Cells Loaded in Nanofibrous Conduit As Potential Candidate for Sciatic Nerve Regeneration, Journal of Molecular Neuroscience (2019)
49. Patterning the Surface Roughness of a Nano Fibrous Scaffold for Transdermal Drug Release, International Journal of Nano Dimension (2019)
50. Reinforcing Mechanical Strength of Electrospun Chitosan Nanofibrous Scaffold Using Cellulose Nanofibers, Journal of Nano Research (2018)