Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Comparison of the Effect of Cycloplegic Versus Nsaid Eye Drops on Pain After Photorefractive Keratectomy Publisher



Abri Aghdam K1, 2 ; Aghaei H1 ; Shokrollahi S1 ; Joshaghani M1 ; Nazari H3 ; Hashemi M1 ; Ghaempanah MJ1
Authors

Source: Journal of Current Ophthalmology Published:2015


Abstract

Purpose: To compare the effect of Homatropine and Diclofenac eye drops for reducing pain after photorefractive keratectomy (PRK). Methods: This randomized, double-masked, interventional study included 32 patients (64 eyes) who underwent bilateral PRK. After operation, patients received Homatropine eye drops in one eye and Diclofenac eye drops in the fellow eye for 48 h. The level of pain was evaluated using visual analogue scale (VAS), verbal rating scale (VRS), and pain rating index (PRI) at 0.5, 24, and 48 h after operation. Results: The level of pain was statistically similar between the two eyes half an hour after operation; however, Diclofenac eyes had significantly less pain 24 h after operation (1.7 ± 1.4 vs 5.8 ± 2.1, P < 0.001 for VAS, 0.6 ± 0.6 vs 2.4 ± 1.1, P < 0.001 for VRS, and 3.4 ± 3.4 vs 12.0 ± 6.9, P < 0.001 for PRI, respectively). Also, 48 h after surgery, the pain scores were less in the Diclofenac eyes (1.6 ± 1.8 vs 3.4 ± 2.8, P < 0.001 for VAS, 0.6 ± 0.6 vs 1.2 ± 0.9, P < 0.001 for VRS, and 3.3 ± 3.7 vs 6.5 ± 6.2, P < 0.001 for PRI). No case with delayed epithelial healing in both groups was observed. Conclusion: The effect of Homatropine seems to be lower compared to Diclofenac for reducing pain after photorefractive keratectomy. © 2015 Iranian Society of Ophthalmology.
Other Related Docs
7. Post-Photorefractive Keratectomy Pain and Corneal Sub-Basal Nerve Density, Journal of Ophthalmic and Vision Research (2017)
14. Effect of Belin-Ambrosio Deviation Index on 2-Year Refractive Outcomes of Prk, Journal of Cataract and Refractive Surgery (2024)