Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Magnetic Bioactive Glasses/Cisplatin Loaded-Chitosan (Cs)-Grafted- Poly (Ε-Caprolactone) Nanofibers Against Bone Cancer Treatment Publisher Pubmed



Amini Z1 ; Rudsary SS2 ; Shahraeini SS3 ; Dizaji BF4 ; Goleij P5 ; Bakhtiari A6 ; Irani M7, 8 ; Sharifianjazi F9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari, Iran
  6. 6. Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
  7. 7. Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
  8. 8. Dentistry Clinical Research Development Unit, Alborz University of Medical Sciences, Karaj, Iran
  9. 9. Department of Materials and Metallurgical Engineering, Amirkabir University of Technology, Tehran, Iran

Source: Carbohydrate Polymers Published:2021


Abstract

The bioactive glasses (BGs)/Cisplatin and magnetic bioactive glasses (MBGs)/Cisplatin were doped into the chitosan (CS)-grafted- poly (ε-caprolactone) (PCL) nanofibers for controlled release of Cisplatin under various pH values and temperatures. The simultaneous effect of chemotherapy and hyperthermia was investigated against MG-63 osteosarcoma cells by treating of cells with Cs-g-PCL/MBGs/Cisplatin under an alternating magnetic field. The synthesized nanofibers were characterized using XRD, FTIR, 1H NMR, SEM, and EDX analysis. The bioactivity, and drug loading efficiency of fibers were investigated. There was no initial burst release of Cisplatin from BGs/Cisplatin and MBGs/Cisplatin loaded Cs-g-PCL/MBGs nanofibers and the Cisplatin release rate was accelerated under pH of 5.5 and temperature of 43 °C compared with physiological condition. The apoptotic/necrotic effect indicated that 100 μg mL−1 nanofibers was optimum for killing of MG-63 cells. The future researches could be focused on the application of nanofibers as an implantable device next to a bone tumor for bone cancer therapy in vivo. © 2021 Elsevier Ltd
Related Docs
View other Related Docs
1. Mesoporous Bioactive Glasses (Mbgs) in Cancer Therapy: Full of Hope and Promise, Materials Letters (2019)
2. Electrospun Gold Nanorods/Graphene Oxide Loaded-Core-Shell Nanofibers for Local Delivery of Paclitaxel Against Lung Cancer During Photo-Chemotherapy Method, European Journal of Pharmaceutical Sciences (2021)
3. Fabrication of Poly(Ε-Caprolactone)/Paclitaxel (Core)/Chitosan/Zein/Multi-Walled Carbon Nanotubes/Doxorubicin (Shell) Nanofibers Against Mcf-7 Breast Cancer, Polymers for Advanced Technologies (2023)
4. Functionalization and Surface Modifications of Bioactive Glasses (Bgs): Tailoring of the Biological Response Working on the Outermost Surface Layer, Materials (2019)
5. Adsorption, and Controlled Release of Doxorubicin From Cellulose Acetate/Polyurethane/Multi-Walled Carbon Nanotubes Composite Nanofibers, Nanotechnology (2022)
6. Simultaneous Controlled Release of 5-Fu, Dox and Ptx From Chitosan/Pla/5-Fu/G-C3n4-Dox/G-C3n4-Ptx Triaxial Nanofibers for Breast Cancer Treatment in Vitro, Colloids and Surfaces B: Biointerfaces (2019)
7. Incorporation of Magnetic Nax Zeolite/Dox Into the Pla/Chitosan Nanofibers for Sustained Release of Doxorubicin Against Carcinoma Cells Death in Vitro, International Journal of Biological Macromolecules (2019)
8. Synthesis of Magnetic Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane/Poly(N-Isopropylacrylamide)-Grafted-Chitosan Core-Shell Nanofibers for Controlled Release of Paclitaxel and 5-Fu, International Journal of Biological Macromolecules (2020)
Experts (# of related papers)
View all Related Experts
Mohammad Akrami (4)
Ismaeil Haririan (3)
Other Related Docs
9. Iron (Fe)-Doped Mesoporous 45S5 Bioactive Glasses: Implications for Cancer Therapy, Translational Oncology (2022)
10. Wound Healing Improvement by Curcumin-Loaded Electrospun Nanofibers and Bfp-Mscs As a Bioactive Dressing, Polymers for Advanced Technologies (2020)
11. Nanofiber-Based Systems Against Skin Cancers: Therapeutic and Protective Approaches, Journal of Drug Delivery Science and Technology (2023)
12. Stimulation of Osteogenic Differentiation of Induced Pluripotent Stem Cells (Ipscs) Using Bioactive Glasses: An in Vitro Study, Frontiers in Bioengineering and Biotechnology (2019)
13. Gold Coated Poly (Ε-Caprolactonediol) Based Polyurethane Nanofibers for Controlled Release of Temozolomide, Biomedicine and Pharmacotherapy (2017)
14. Theranostic Applications of Graphene-Based Materials in Lung Cancer: A Review, FlatChem (2025)
15. Synthesis and Physico-Chemical Characterization of Fluoride (F)- a Nd Silver (Ag)-Substituted Sol-Gel Mesoporous Bioactive Glasses, Biomedical Glasses (2019)
16. A Novel Biocompatible Drug Delivery System of Chitosan/Temozolomide Nanoparticles Loaded Pcl-Pu Nanofibers for Sustained Delivery of Temozolomide, International Journal of Biological Macromolecules (2017)
17. A Comparative Investigation on Bioactivity and Antibacterial Properties of Sol-Gel Derived 58S Bioactive Glass Substituted by Ag and Zn, Silicon (2019)
18. The Sustained Delivery of Temozolomide From Electrospun Pcl-Diol-B-Pu/Gold Nanocompsite Nanofibers to Treat Glioblastoma Tumors, Materials Science and Engineering C (2017)