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Mesoporous Bioactive Glasses (Mbgs) in Cancer Therapy: Full of Hope and Promise Publisher



Kargozar S1 ; Mozafari M2, 3, 4 ; Hamzehlou S5 ; Kim HW6, 7, 8 ; Baino F9
Authors
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Authors Affiliations
  1. 1. Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 917794-8564, Iran
  2. 2. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 4777-141 55, Tehran, Iran
  3. 3. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  5. 5. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 14155-6447, Iran
  6. 6. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea
  7. 7. Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, South Korea
  8. 8. Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, South Korea
  9. 9. Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino, 10129, Italy

Source: Materials Letters Published:2019


Abstract

Implementing novel approaches for cancer therapy are under continuous progress, and bioactive glasses (BGs) and glass-ceramics show excellent potential in this regard. Although these materials have been mostly used as magnetic substances in hyperthermia approach, some of their subsets, i.e., mesoporous bioactive glasses (MBGs), have been recently proposed not only as magnetic materials but also as drug delivery systems for advanced treatment of bone cancer. Different types of MBGs including granular particles and three-dimensional (3D) scaffolds can be applied for cancer therapy. Based on the results obtained from in vitro studies, MBGs seem to have a bright future in the therapeutic strategies to combat cancer; however, their application in this field is still in its beginning, and more research needs to reveal all pros and cons of this newly proposed approach. © 2019 Elsevier B.V.
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