Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Role of Vitamin D in Pathogenesis and Severity of Covid-19 Infection Publisher Pubmed



Honardoost M1, 2 ; Ghavideldarestani M1 ; Khamseh ME1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrine Research Center, Institute of Endocrinology and Metabolism, University of Medical Sciences, Tehran, Iran
  2. 2. Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2023


Abstract

Coronavirus disease (COVID-19) is an infectious disease caused by a new virus that causes respiratory illness. Older adults and individuals who have pre-existing chronic medical conditions are at higher risk for more serious complications from COVID-19. Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, cardiovascular events and associated comorbidities, which are the main causes of severe clinical complications in COVID-19 patients. Considering the defensive role of vitamin D, mediated through modulation of the innate and adaptive immune system as well as inhibition of the Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Nutritional Approach for Increasing Public Health During Pandemic of Covid-19: A Comprehensive Review of Antiviral Nutrients and Nutraceuticals, Health Promotion Perspectives (2021)
2. Vitamin D Effects on Immune Response Against Covid-19 and Influenza Infection: A Review, Bioactive Compounds in Health and Disease (2020)
3. Vitamin D and Covid-19: From Potential Therapeutic Effects to Unanswered Questions, Reviews in Medical Virology (2021)
4. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
5. A Review of Covid-19: The Main Ways of Transmission and Some Prevention Solutions, Clinical Symptoms, More Vulnerable Human Groups, Risk Factors, Diagnosis, and Treatment, Journal of Environmental Treatment Techniques (2020)
6. Possible Association of Vitamin D Status With Lung Involvement and Outcome in Patients With Covid-19: A Retrospective Study, European Journal of Nutrition (2021)
7. Altered Immunoemotional Regulatory System in Covid-19: From the Origins to Opportunities, Journal of Neuroimmunology (2021)
8. Immunomodulatory Effects of Vitamin D in Influenza Infection, Current Immunology Reviews (2018)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Marziyeh Pazoki (3)
Other Related Docs
9. The Prophylaxis and Treatment Potential of Supplements for Covid-19, European Journal of Pharmacology (2020)
10. The Predictive Power of Serum Vitamin D for Poor Outcomes in Covid-19 Patients, Food Science and Nutrition (2021)
11. The Interplay Between Vitamin D and Viral Infections, Reviews in Medical Virology (2019)
12. Molecular Mechanisms and Therapeutic Effects of Different Vitamins and Minerals in Covid-19 Patients, Journal of Trace Elements in Medicine and Biology (2022)
13. Treatment With 25-Hydroxyvitamin D3 (Calcifediol) Is Associated With a Reduction in the Blood Neutrophil-To-Lymphocyte Ratio Marker of Disease Severity in Hospitalized Patients With Covid-19: A Pilot Multicenter, Randomized, Placebo-Controlled, Double-Blinded Clinical Trial, Endocrine Practice (2021)
14. Vitamin D Sufficiency, a Serum 25-Hydroxyvitamin D at Least 30 Ng/Ml Reduced Risk for Adverse Clinical Outcomes in Patients With Covid-19 Infection, PLoS ONE (2020)
15. The Possible Double-Edged Sword Effects of Vitamin D on Covid-19: A Hypothesis, Cell Biology International (2021)
16. Association Between Cardiometabolic Risk Factors and Covid-19 Susceptibility, Severity and Mortality: A Review, Journal of Diabetes and Metabolic Disorders (2021)
17. Nutrition and Immunity in Covid-19, Advances in Experimental Medicine and Biology (2021)
18. Vitamin D Supplementation in Covid-19: A Friend or Foe?, EXCLI Journal (2020)
19. Circulating Vitamin D and the Risk of Gestational Diabetes: A Systematic Review and Dose-Response Meta-Analysis, Endocrine (2020)
20. The Effect of Vitamin D Deficiency State on Oxidized Low-Density Lipoprotein Alteration in Patients With Type 2 Diabetes, Functional Foods in Health and Disease (2021)
21. Air Pollution, Environmental Chemicals, and Smoking May Trigger Vitamin D Deficiency: Evidence and Potential Mechanisms, Environment International (2019)
22. Association of Serum 25-Hydroxy Vitamin D Status With Cardiometabolic Risk Factors and Total and Regional Obesity in Southern Iran: Evidence From the Pocosteo Study, Scientific Reports (2024)
23. Shining a Light on Selenium: A Meta-Analysis of Supplementation in Multiple Sclerosis, Biological Trace Element Research (2023)
24. The Prevalence of Electrolyte Imbalances and Their Relationship With Disease Severity in Hospitalized Covid-19 Patients, Archives of Clinical Infectious Diseases (2022)
25. The Association Between the Level of Serum 25(Oh) Vitamin D, Obesity, and Underlying Diseases With the Risk of Developing Covid-19 Infection: A Case–Control Study of Hospitalized Patients in Tehran, Iran, Journal of Medical Virology (2021)
26. Serum Vitamin D Levels and Their Correlation With Pro-Inflammatory Prostaglandins in Acute Myeloid Leukemia: A Cross-Sectional Analysis, Scientific Reports (2024)
27. Classification of the Present Pharmaceutical Agents Based on the Possible Effective Mechanism on the Covid-19 Infection, DARU# Journal of Pharmaceutical Sciences (2020)
28. Association of Serum Level of 25-Hydroxy Vitamin D Deficiency and Pulmonary Function in Healthy Individuals, Scientific World Journal (2018)
29. Evaluation of the Prevalence of Illness Anxiety Disorder Following the Covid-19 Pandemic in Iran and Its Related Factors: A Cross-Sectional Study, Health Science Reports (2023)
30. Effects of Vitamin D Deficiency on Left Atrial Function As Evaluated by 2D Speckle-Tracking Echocardiography, Journal of Clinical Ultrasound (2018)
31. Covid-19 Infection and Vitamin D: Current Scenario and Future Prospects, Current Drug Discovery Technologies (2021)
32. Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives, Journal of Immunology Research (2022)
33. The Association Between Baseline Vitamin D Level and Clinical Outcomes in Patients With Covid-19 a 7-Month Follow-Up Cohort Study, Topics in Clinical Nutrition (2024)
34. Harmony of Operations of Some Vitamins in Controlling the 2019-Ncov Virus Based on Scientific Reports, Chemical Review and Letters (2020)
35. Vitamin D Role in Hepatitis B: Focus on Immune System and Genetics Mechanism, Heliyon (2022)
36. Circulating Levels of Il-35 and Gene Expression of Foxp3 in Coronary Artery Disease: Is There Any Interplay Between Them and 25-Hydroxyvitamin D3?, Clinical Laboratory (2018)
37. Emerging Advances of Nanotechnology in Drug and Vaccine Delivery Against Viral Associated Respiratory Infectious Diseases (Varid), International Journal of Molecular Sciences (2021)
38. The Evaluation of Clinical Symptoms and Underlying Factors in Infected Patients With Covid-19, Tehran University Medical Journal (2021)
39. Impact of Supplementation With Multivitamin-Mineral Specially Formulated to Improve Fatigue and Inflammatory State in Patients With Multiple Sclerosis: A Triple-Blind, Randomized, Placebo-Controlled Trial, Current Journal of Neurology (2020)
40. Association of Vitamin D Receptor Gene Polymorphisms and Clinical/Severe Outcomes of Covid-19 Patients, Infection# Genetics and Evolution (2021)
41. Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females, BMC Research Notes (2021)
42. Vitamin D Status and All-Cause Mortality in Patients With Chronic Kidney Disease: A Systematic Review and Dose-Response Meta-Analysis, Journal of Clinical Endocrinology and Metabolism (2017)
43. The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study, Iranian Journal of Pharmaceutical Research (2020)
44. Vitamin D Supplementation and Calcium: Many-Faced Gods or Nobody in Fighting Against Corona Virus Disease 2019, Clinical Nutrition ESPEN (2024)
45. The Effect of Vitamin D Supplementation on Serum Levels of Anti-Mullerian Hormone, Journal of Babol University of Medical Sciences (2025)
46. Dietary Patterns and Micronutrients in Respiratory Infections Including Covid-19: A Narrative Review, BMC Public Health (2024)
47. A Review on an Ongoing Pandemic Caused by the Severe Acute Respiratory Syndrome Coronavirus 2: The Pathogenesis, Epidemiology, Immunological Features, and Currently Available Diagnostic Tests, Reviews and Research in Medical Microbiology (2022)
48. The Association of Vitamin D Status With Lipid Profile and Inflammation Biomarkers in Healthy Adolescents, Nutrients (2020)
49. The Possible Role of Vitamin D Deficiency in Early Implant Failure, BioMed Research International (2021)
50. Immunomodulatory Actions of Vitamin D in Various Immune-Related Disorders: A Comprehensive Review, Frontiers in Immunology (2023)