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Bacteria-Derived Chimeric Toxins As Potential Anticancer Agents Publisher



Khoshnood S1 ; Fathizadeh H2, 3 ; Neamati F4 ; Negahdari B5 ; Baindara P6 ; Abdullah MA7 ; Haddadi MH1
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Authors Affiliations
  1. 1. Clinical Microbiology Research Centre, Ilam University of Medical Sciences, Ilam, Iran
  2. 2. Student Research Committee, Sirjan School of Medical Sciences, Sirjan, Iran
  3. 3. Department of Laboratory Sciences, Sirjan School of Medical Sciences, Sirjan, Iran
  4. 4. Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, United States
  7. 7. Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam Campus, Kepala Batas, Pulau Pinang, Malaysia

Source: Frontiers in Oncology Published:2022


Abstract

Cancer is one of the major causes of death globally, requiring everlasting efforts to develop novel, specific, effective, and safe treatment strategies. Despite advances in recent years, chemotherapy, as the primary treatment for cancer, still faces limitations such as the lack of specificity, drug resistance, and treatment failure. Bacterial toxins have great potential to be used as anticancer agents and can boost the effectiveness of cancer chemotherapeutics. Bacterial toxins exert anticancer effects by affecting the cell cycle and apoptotic pathways and regulating tumorigenesis. Chimeric toxins, which are recombinant derivatives of bacterial toxins, have been developed to address the low specificity of their conventional peers. Through their targeting moieties, chimeric toxins can specifically and effectively detect and kill cancer cells. This review takes a comprehensive look at the anticancer properties of bacteria-derived toxins and discusses their potential applications as therapeutic options for integrative cancer treatment. Copyright © 2022 Khoshnood, Fathizadeh, Neamati, Negahdari, Baindara, Abdullah and Haddadi.
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