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Estimation of Genetic Variation in the Secretor and Lewis Genes in Iranian Hospitalized Children Publisher Pubmed



Farahmand M1 ; Jalilvand S1 ; Arashkia A2 ; Izadi A3 ; Forouzannia SM4 ; Mollaeikandelous Y5 ; Shoja Z2
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Molecular Virology, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Pediatric Infectious diseases, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Transfusion Clinique et Biologique Published:2021


Abstract

Background: The Secretor (FUT2) and lewis gene (FUT3) are in charge of the construction of histo-blood group antigens, which act as a receptor for some Pathogenes. This study aimed to estimate the prevalence of five significant single nucleotide polymorphisms (SNPs) in Iranian children. Methods: In this cross-sectional study, 102 blood samples collected from hospitalized children. The FUT2 gene region was amplified and sequenced to explore rs1047781 and rs601338, and the FUT3 gene region was amplified to explore rs28362459, rs812936, rs778986 SNPs. Results: In FUT2 gene, Se358,428 that produces Se phenotype with 63% (0.53 - 0.72) prevalence, was the most common genotype. For FUT3 gene Le59,202,314 with 80% prevalence was most common genotype (0.71 - 0.87). Conclusion: This study genotyped Secretor and Lewis genes and designated SNPs’ distinct distribution in Iran, and clarified at-risk groups for certain diseases. © 2020 Societe francaise de transfusion sanguine (SFTS)
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