The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population

The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population Publisher

Akbari Z¹ ; Safarialighiarloo N² ; Aghdaei HA³ ; Vahedi M⁴ ; Haghighi MM¹ ; Borkheili MM¹ ; Nazemalhosseinimojarad E¹ ; Zali MR¹

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1. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
3. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2020

Abstract

Aim: Our aim was to investigate the association between two single nucleotide polymorphisms (SNPs) of SMAD7 and the risk of CRC among Iranian individuals. Background: Genome-wide association studies (GWAS) have identified 18q21 as a risk locus for colorectal cancer (CRC), which maps to the SMAD7 gene. Methods: This case-control study was conducted on 109 CRC cases and 109 controls in the Iranian population to evaluate the influence of two SNPs of SMAD7, rs2337106 and rs6507874, on the risk of CRC as well as on clinicopathological features. Genotype determination was performed by TaqMan assay via an ABI 7500 Real Time PCR System (Applied Biosystems) for the DNA of peripheral blood. Descriptive analysis and logistic regression model were used for statistical analyses. Results: Genotyping of the SNPs in the SMAD7 gene revealed that the frequency of G allele of rs2337106 was 53.7% in controls and 56.4% in cases (p-value=0.564) while the frequency of C allele of rs6507874 was 55.5% in controls and 56.3% in cases (pvalue= 0.772). Further, there were no significant differences in genotype frequencies of these SNPs between CRC patients and controls. The SMAD7 genotypes were not associated with the risk of CRC or with any clinicopathological characteristics such as tumor site, tumor grade, and stage TNM in CRC patients (p-value>0.05), even after adjustment for sex, age, and smoking status. Conclusion: Our results provided the first evidence that SMAD7 genotypes, rs2337106 and rs6507874, could not be predisposing markers in genetic susceptibility to CRC in an Iranian population, at least in the studied population. © 2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.

2. Advanced Colonic Neoplasia in the First Degree Relatives of Colon Cancer Patients: A Colonoscopy-Based Study, International Journal of Cancer (2016)

3. Alternative Splicing of the Occ-1 Gene Generates Three Splice Variants and a Novel Exonic Microrna, Which Regulate the Wnt Signaling Pathway, RNA (2017)

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Style	Citing Format
MLA	Akbari Z, et al.. "The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population." Gastroenterology and Hepatology from Bed to Bench, vol. 13, no. 1, 2020, pp. 23-30.
APA	Akbari Z, Safarialighiarloo N, Aghdaei HA, Vahedi M, Haghighi MM, Borkheili MM, Nazemalhosseinimojarad E, Zali MR (2020). The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population. Gastroenterology and Hepatology from Bed to Bench, 13(1), 23-30.
Chicago	Akbari Z, Safarialighiarloo N, Aghdaei HA, Vahedi M, Haghighi MM, Borkheili MM, Nazemalhosseinimojarad E, Zali MR. "The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population." Gastroenterology and Hepatology from Bed to Bench 13, no. 1 (2020): 23-30.
Harvard	Akbari Z et al. (2020) 'The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population', Gastroenterology and Hepatology from Bed to Bench, 13(1), pp. 23-30.
Vancouver	Akbari Z, Safarialighiarloo N, Aghdaei HA, Vahedi M, Haghighi MM, Borkheili MM, et al.. The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population. Gastroenterology and Hepatology from Bed to Bench. 2020;13(1):23-30.
BibTex	@article{ author = {Akbari Z and Safarialighiarloo N and Aghdaei HA and Vahedi M and Haghighi MM and Borkheili MM and Nazemalhosseinimojarad E and Zali MR}, title = {The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population}, journal = {Gastroenterology and Hepatology from Bed to Bench}, volume = {13}, number = {1}, pages = {23-30}, year = {2020} }
RIS	TY - JOUR AU - Akbari Z AU - Safarialighiarloo N AU - Aghdaei HA AU - Vahedi M AU - Haghighi MM AU - Borkheili MM AU - Nazemalhosseinimojarad E AU - Zali MR TI - The Association Between Smad7 Polymorphisms and Colorectal Cancer Susceptibility As Well As Clinicopathological Features in the Iranian Population JO - Gastroenterology and Hepatology from Bed to Bench VL - 13 IS - 1 SP - 23 EP - 30 PY - 2020 ER -

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