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Renal Cell Carcinoma: An Overview of the Epidemiology, Diagnosis, and Treatment Pubmed



Bahadoram S1 ; Davoodi M2 ; Hassanzadeh S1 ; Bahadoram M3 ; Barahman M3 ; Mafakher L1
Authors
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Authors Affiliations
  1. 1. Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Radiology, School of Medicine, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran
  3. 3. Department of Radiation Oncology, Firoozgar Hospital, Firoozgar Clinical Research Development Center (FCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran

Source: Giornale Italiano di Nefrologia Published:2022


Abstract

Renal cell carcinoma (RCC) is the most common type of urogenital cancer. It has a mortality rate of 30- 40% and is more commonly seen in men than women. In addition to gender, other risk factors of RCC include obesity, hypertension, smoking, and chronic kidney disease. Following the improvements in diagnostic tests, such as CT and MRI imaging, the incidence of patients diagnosed with RCC has rapidly increased over the past decades. The most common type of RCC, based on histological and molecular subtypes, is clear cell carcinoma which occurs frequently due to mutations in the VHL gene. Nephronsparing surgery is a selective technique to maintain kidneys in patients while radical nephrectomy and partial nephrectomy are used to remove small tumors. In addition to surgical approaches, adjuvant therapy and targeted therapy are applied in patients with metastatic RCC. In this review, we give an overview of the most recent research on RCC which would help physicians to better manage patients with RCC. © 2022 Societa Italiana di Nefrologia - Anno 39 Volume 3 n° 3.
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2. Tumor Immunology, Clinical Immunology (2022)
3. Immunotherapy in Bladder and Renal Cancers, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)
5. Cancer Immunology, Encyclopedia of Infection and Immunity (2022)
6. Nephrectomy and Ivc Thrombectomy in Renal Cancer: A Narrative Review, Clinical and Translational Oncology (2024)
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