Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose

Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose Publisher

Mousavizadegan M¹ ; Azimzadeh Asiabi P² ; Hosseini M¹ ; Khoobi M³

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1. Department of Life Science Engineering, Faculty of New Sciences & Technologies University of Tehran, Tehran, Iran
2. Department of Chemistry, University of Zanjan, Zanjan, Iran
3. Biomaterials Group, Pharmaceutical Research Center The Institute of Pharmaceutical Sciences (TIPS) Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: ChemistrySelect Published:2020

Abstract

Nanozymes have fascinated increasing attention in the field of enzyme based detection methods. In this study, we have focused on developing a rapid, colorimetric sensing method using peroxidase mimicking nanostructures for the visual detection of glucose molecules in biological samples. For this, using Fe3O4 and silk fibroin proteins, magnetic silk nanostructures (MSF nanostructures) were specifically tailored. Given their ability of catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide, they can be used as colorimetric catalysts in the detection of glucose based on the production of H2O2. Using MSF nanostructures, glucose molecules were detected by both the naked eye and UV-Vis spectrophotometry in concentrations ranging from 1.4 to 86.0 μM, with a detection limit of 0.5 μM and a good linear relationship (R2=0.988). In conclusion, it can be stated that the proposed nanostructure holds great potential for biosensing applications. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Style	Citing Format
MLA	Mousavizadegan M, et al.. "Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose." ChemistrySelect, vol. 5, no. 27, 2020, pp. 8093-8098.
APA	Mousavizadegan M, Azimzadeh Asiabi P, Hosseini M, Khoobi M (2020). Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose. ChemistrySelect, 5(27), 8093-8098.
Chicago	Mousavizadegan M, Azimzadeh Asiabi P, Hosseini M, Khoobi M. "Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose." ChemistrySelect 5, no. 27 (2020): 8093-8098.
Harvard	Mousavizadegan M et al. (2020) 'Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose', ChemistrySelect, 5(27), pp. 8093-8098.
Vancouver	Mousavizadegan M, Azimzadeh Asiabi P, Hosseini M, Khoobi M. Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose. ChemistrySelect. 2020;5(27):8093-8098.
BibTex	@article{ author = {Mousavizadegan M and Azimzadeh Asiabi P and Hosseini M and Khoobi M}, title = {Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose}, journal = {ChemistrySelect}, volume = {5}, number = {27}, pages = {8093-8098}, year = {2020} }
RIS	TY - JOUR AU - Mousavizadegan M AU - Azimzadeh Asiabi P AU - Hosseini M AU - Khoobi M TI - Synthesis of Magnetic Silk Nanostructures With Peroxidase-Like Activity As an Approach for the Detection of Glucose JO - ChemistrySelect VL - 5 IS - 27 SP - 8093 EP - 8098 PY - 2020 ER -

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