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Effects of Probiotics and Synbiotic Supplementation on Antioxidant Status: A Meta-Analysis of Randomized Clinical Trials Publisher Pubmed



Roshan H1 ; Ghaedi E2, 3 ; Rahmani J1 ; Barati M1 ; Najafi M1 ; Karimzedeh M4 ; Nikpayam O5
Authors
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Authors Affiliations
  1. 1. Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biochemistry and Diet Therapy, Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Clinical Nutrition ESPEN Published:2019


Abstract

Background and aim: Oxidative stress implicated in the pathogenesis of several diseases. Anti-oxidative characteristics of probiotics reported previously. Thus, we aimed to critically investigate the effectiveness of probiotics and synbiotics supplementation on antioxidant biomarkers. Methods: A comprehensive search of Scopus and Medline was performed up to November 2017. All randomized controlled trials (RCT) which evaluate the effect of probiotics or synbiotics on superoxide dismutase (SOD) activity, total antioxidant capacity (TAC) and glutathione (GSH) levels were included. Weighted mean difference (WMD) were pooled using random effect model. Results: Sixteen eligible RCTs with 915 participants were included in present study. Findings showed that probiotics could significantly increase GSH level compared to the control groups ((WMD): 132.36, 95% CI: 27.76, 236.95, P = 0.01). Because of considerable heterogeneity among included the studies, subgroup analyses were conducted. Subgroup analysis revealed that GSH level significantly increased in non-diabetic individuals; the effect size was not significant in diabetic patients. Furthermore, probiotics and synbiotics showed no significant effect on TAC level (WMD: 0.04, 95% CI: −0.07, 0.15, P: 0.50) and SOD activity (WMD: 0.04, 95% CI: −0.06, 0.13, P = 0.43). Conclusion: Probiotics and synbiotics supplementation improve GSH as a biomarkers of antioxidant status in the body. However, additional studies needed for concluding about TAC and SOD activity. © 2019 European Society for Clinical Nutrition and Metabolism
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