Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation

Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation Publisher Pubmed

Saadat E¹ ; Shakor N¹ ; Gholami M² ; Dorkoosh FA^{1, 3}

Show Affiliations

1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Medical Biomaterial Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Pharmaceutics Published:2015

Abstract

A novel triamcinolone loaded polymeric micelle was synthesized based on hyaluronic acid and phospholipid for articular delivery. The newly developed micelle was characterized for physicochemical properties including size, zeta potential, differential scanning calorimetry (DSC) analysis and also morphology by means of transmission electron microscopy. The biocompatibility of micelle was explored by histopathological experiment in rat model. Also biological fate of micelle was investigated in rat by means of real time in vivo imaging system. Triamcinolone loaded micelle was in the size range of 186 nm with negative zeta potential charge. Micelles were spherical in shape with core shell like structure. Triamcinolone was released from micelle during 76 h with almost low burst effect. DSC analysis showed the conversion of crystalline triamcinolone from its crystalline state. Histopathological analysis showed no evidence of tissue damage or phagocytic accumulation in knee joint of rat. The real time in vivo imaging analysis suggested at least three days retention time of micellar system in knee joint post injection. © 2015 Elsevier B.V. All rights reserved.

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Style	Citing Format
MLA	Saadat E, et al.. "Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation." International Journal of Pharmaceutics, vol. 489, no. 1-2, 2015, pp. 218-225.
APA	Saadat E, Shakor N, Gholami M, Dorkoosh FA (2015). Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation. International Journal of Pharmaceutics, 489(1-2), 218-225.
Chicago	Saadat E, Shakor N, Gholami M, Dorkoosh FA. "Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation." International Journal of Pharmaceutics 489, no. 1-2 (2015): 218-225.
Harvard	Saadat E et al. (2015) 'Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation', International Journal of Pharmaceutics, 489(1-2), pp. 218-225.
Vancouver	Saadat E, Shakor N, Gholami M, Dorkoosh FA. Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation. International Journal of Pharmaceutics. 2015;489(1-2):218-225.
BibTex	@article{ author = {Saadat E and Shakor N and Gholami M and Dorkoosh FA}, title = {Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation}, journal = {International Journal of Pharmaceutics}, volume = {489}, number = {1-2}, pages = {218-225}, year = {2015} }
RIS	TY - JOUR AU - Saadat E AU - Shakor N AU - Gholami M AU - Dorkoosh FA TI - Hyaluronic Acid Based Micelle for Articular Delivery of Triamcinolone, Preparation, in Vitro and in Vivo Evaluation JO - International Journal of Pharmaceutics VL - 489 IS - 1-2 SP - 218 EP - 225 PY - 2015 ER -

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