Encapsulation of Docetaxel Into Diblock Polymeric Polymersome As a Nanodrug Publisher



Haghshenas V¹ ; Sariri R¹ ; Naderi Sohi A² ; Nazari H³ Show Affiliations
Source: ChemistrySelect Published:2020

Abstract

In this study, a chemotherapeutic drug, Docetaxel (DTX) was loaded in a di-block polymeric nanoparticles (NPs) consisted of Oleate and Poly (ethylene glycol). First, the OA-PEG1000 units were synthesized by the esterification reaction and confirmed by 1HNMR and FTIR spectroscopies. After determination of critical micelle concentration (CMC), the DTX was loaded into the OA-PEG1000 NPs using the solvent displacement method. The encapsulation efficiency and loading capacity percentages were estimated as 22.2 % and 0.43 % respectively. The average size (obtained by DLS) and zeta potential of NPs were as 221.3±8.06 nm and 6.31±0.29 mV respectively indicating polymersome formation. The morphology of NPs in AFM images was almost spherical with a diameter of about 207.1±28.36 nm which was approximate to DLS outcomes. These results demonstrated that di-block polymeric NPs can be potentially practical for carrying and delivering DTX as a novel anticancer pharmaceutical. © 2020 Wiley-VCH GmbH