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Phytochemical Analysis, Antimicrobial, Antioxidant Activities and Total Phenols of Ferulago Carduchorum in Two Vegetative Stages (Flower and Fruit) Pubmed



Golfakhrabadi F1 ; Ardekani MRS1, 2 ; Saeidnia S3 ; Yousefbeyk F4 ; Jamalifar H5 ; Ramezani N1 ; Akbarzadeh T2, 6 ; Khanavi M1, 7
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Traditional Pharmacy, Faculty of Traditional Medicine and Persian Medicine, Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
  5. 5. Department of Drug and Food Control, Faculty of Pharmacy, Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medicinal Chemistry, Faculty of Pharmacy, Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada

Source: Pakistan Journal of Pharmaceutical Sciences Published:2016


Abstract

Ferulago carduchorum (Apiaceae family) is an endemic plant of Iran. The crude extract and four fractions of aerial parts of F. carduchorum in two vegetative stages (flower and fruit) were studied for their total phenolic contents, antimicrobial and antioxidant activities using folin-ciocalteu assay, micro dilution method and DPPH assay, respectively. The results indicated that the best antioxidant activity was determined in flower crude extract (IC50=0.44mg/mL). The flower ethyl acetate fraction (FLE) showed better antimicrobial and antifungal activities than other fractions. So, FLE was selected for phytochemical investigations, resulting in isolation of a flavonoid (hesperetin). Hesperetin showed antimicrobial activity. The results showed that the antimicrobial and antioxidant effects during the flowering are obviously more than the fruit season.
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