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Mirnas Derived From Cancer-Associated Fibroblasts in Colorectal Cancer Publisher Pubmed



Savardashtaki A1, 2 ; Shabaninejad Z3 ; Movahedpour A1, 4 ; Sahebnasagh R5 ; Mirzaei H6 ; Hamblin MR7
Authors
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Authors Affiliations
  1. 1. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  7. 7. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 40 Blossom Street, Boston, 02114, MA, United States

Source: Epigenomics Published:2019


Abstract

Currently, the incidence of colorectal cancer (CRC) is increasing across the world. The cancer stroma exerts an impact on the spread, invasion and chemoresistance of CRC. The tumor microenvironment involves a complex interaction between cancer cells and stromal cells, for example, cancer-associated fibroblasts (CAFs). CAFs can promote neoplastic angiogenesis and tumor development in CRC. Mounting evidence suggests that many miRNAs are overexpressed (miR-21, miR-329, miR-181a, miR-199a, miR-382 and miR-215) in CRC CAFs, and these miRNAs can influence the spread, invasiveness and chemoresistance in neighboring tumor cells via paracrine signaling. Herein, we summarize the pathogenic roles of miRNAs and CAFs in CRC. Moreover, for first time, we highlight the miRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis. © 2019 Future Medicine Ltd.
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