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The Effective Function of Circular Rna in Colorectal Cancer Publisher



Amelimojarad M1 ; Amelimojarad M1 ; Hadizadeh M2 ; Young C3 ; Babini H4 ; Nazemalhosseinimojarad E5 ; Bonab MA2
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Basic Science, Kharrazi University, Tehran, Iran
  2. 2. School of Medicine, University of Sunderland, City Campus, Chester Road, Sunderland, SR1 3SD, United Kingdom
  3. 3. Institute of Health & Life Sciences, De Montfort University, Leicester, United Kingdom
  4. 4. Department of Cell & Molecular Biology, Faculty of Science, Tehran University of Medical Science, Tehran, Iran
  5. 5. Gastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Cancer Cell International Published:2021


Abstract

Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC. © 2021, The Author(s).
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