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The Function of Novel Small Non‐Coding Rnas (Pirnas, Trfs) and Piwi Protein in Colorectal Cancer Publisher Pubmed



Amelimojarad M1 ; Amelimojarad M1 ; Wang J1, 2
Authors
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Authors Affiliations
  1. 1. Department Genetic, Medical University of Tehran, Tehran, Iran
  2. 2. Department Molecular Medicine, University of Leeds, England, United Kingdom

Source: Cancer Treatment and Research Communications Published:2022


Abstract

Although great research has been done to clarify the pathogenesis of colorectal cancer (CRC), it is still the third common cancer worldwide. Pathogenesis of CRC as a heterogeneous disease is correlated with mutations and epigenetic alterations that result in the inactivation of tumor‐suppressive and activation of an oncogene. Small non-coding RNAs (sncRNAs), emerging as a key player in regulating the genes and protein expression, with a length less than 200 nucleotide (nt). In this review, we aimed to focus on the role and the biogenesis of PIWI‐interacting RNA (piRNAs), and tRNA‐derived small RNA (tRFs) and PIWI proteins in the initiation, progression, and metastasis of CRC and their molecular mechanisms to understand their function in cancers and to provide better therapeutic strategies for CRC. © 2022
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