Photodynamic Therapies for Cancer Treatment Publisher



Sadiqa A¹ ; Riaz S² ; Rasul A² ; Zara R² ; Afroz K² ; Saeed Z² ; Khan GB³ ; Khorsandi K^{4, 5} ; Ali MY⁶ Show Affiliations
Source: Cancer Targeting Therapies: Conventional and Advanced Perspectives Published:2023

Abstract

Photodynamic therapy (PDT) is a non-invasive and contemporary therapy that relies on the interaction between a photosensitizer (PS) with the combination of applicable wavelength and oxygen that causes cell death. The origin of PDT dates back hundreds of years ago and it is frequently used for the treatment of non-oncological diseases as well as several types of cancers. The use of PDT is based on the application of a PS (photosensitive compound), which has the property to accumulate selectively in abnormal tissues without imposing any damage to normal or healthy tissues. Over the past decade, a trivial acceleration has been observed in the development of the combination of the photosensitizer with nanomaterials, which have the potential to improve the efficiency of PDT and eliminates its side effects as well. This advanced therapeutic technique has been adapted successfully in several medical fields, such as urology, gynecology, dermatology, and oncology. Several clinical studies have revealed the significance of PDT application in early-stage cancers where its application can prolong the survival period and improves the quality of life. © 2024 selection and editorial matter, Muhammad Yasir Ali, Shazia Anwer Bukhari; individual chapters, the contributors.